|Western blot, immunoprecipitation|
Host Species and Isotype:
Glutathione peroxidase 1 (GPX1) is a cytosolic selenoprotein which reduces hydrogen peroxide to water (Ref 1). GPX1 is the most abundant and ubiquitous among the five GPX isoforms identified so far (Ref 2). It is an important component in the anti-oxidative defense in cells and is associated with a variety of disease conditions, such as colon cancer (Ref 3), coronary artery disease (Ref 4) and insulin resistance (Ref 1).
- McClung, J.P. et al. (2004) Proc. Natl. Acad. Sci. USA 101, 8852-8857.
- Hamanishi, T. et al. (2004) Diabetes 53, 2455-2460.
- Drew, J.E. et al. (2005) FEBS Lett. 579, 6135-6139.
- Winter, J.P. et al. (2003) Coron. Artery Dis. 14, 149-153.