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This is a purified rabbit anti-mouse TNFRSFS7 Polyclonal Antibody, that can be used in the validated applications of Western blot, ELISA, and immunohistochemistry. This TNFRSFS7 Polyclonal Antibody was produced in rabbits immunized with purified, recombinant mouse TNFRSFS7. TNFRSFS7 specific IgG was purified by mouse TNFRSFS7 affinity chromatograpy.
Antibody characteristics include:
Applications: This TNFRSFS7 Polyclonal Antibody, has been validated for use in Western blot, ELISA, and immunohistochemistry Host species and isotype: This is a rabbit Polyclonal IgG against mouse TNFRSFS7 Immunogen: Recombinant mouse TNFRSFS7 protein Product size: 100 µg
mouse CD27, also known as TNFRSF7, is a member of the tumor necrosis factor receptor (TNFR) superfamily characterized by the presence of a Cys-knot motif in the extracellular region, which occurs three times in CD27. CD27 is a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, and has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis. CD27 has been defined as a T and B cell co-stimulatory molecule, and its activity is governed by the transient availability of its TNF-like ligand CD70 on lymphocytes and dendritic cells. In man and mouse, CD27 is restricted to lymphoid cells and present on the great majority of naive CD4+ and CD8 + T cells. CD27 may contribute to normal murine T cell development by synergizing with the pre-TCR-mediated signal, since the CD27/CD70 receptor-ligand pair cooperates with the TCR in the regulation of the peripheral T cell response. Murine CD27 shows an identity of 65% in aa sequence compared with human CD27