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This is a purified mouse anti-human TROP2 Monoclonal Antibody that can be used in the validated applications of Western blot, immunohistochemistry and immunocytochemistry. This TROP2 Monoclonal Antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant human TROP2 extracellular domain. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Antibody characteristics include:
Applications: This TROP2 Monoclonal Antibody has been validated for use in Western blot, immunohistochemistry and immunocytochemistry Host species and isotype: This is a mouse Monoclonal IgG1 against human TROP2 Clone ID of monoclonal antibody (mAb): The TROP2 monoclonal antibody clone ID is 8C6C1D7 Immunogen: Recombinant human TROP2 protein Product size: 100 µg
human TROP2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed by human carcinomas. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. The cytoplasmic tail of TROP2 possesses potential serine and tyrosine phosphorylation sites and a conserved phosphatidyl-inositol binding consensus sequence. TROP2 transduces an intracellular calcium signal and acts as a cell surface receptor, meanwhile is involved in the regulation of cell- cell adhesion. Accordingly, as a widespread stimulator of human cancer growth and a unique marker and causal factor of metastatic cancer, TROP2 is a possible candidate for diagnosis and molecular target therapy. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.