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This is a purified rabbit anti-human PTH1R Polyclonal Antibody, that can be used in the validated applications of Western blot, ELISA, and immunohistochemistry. This PTH1R Polyclonal Antibody was produced in rabbits immunized with purified, recombinant human PTH1R. PTH1R specific IgG was purified by human PTH1R affinity chromatograpy.
Antibody characteristics include:
Applications: This PTH1R Polyclonal Antibody, has been validated for use in Western blot, ELISA, and immunohistochemistry Host species and isotype: This is a rabbit Polyclonal IgG against human PTH1R Immunogen: Recombinant human PTH1R protein Product size: 100 µg
Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane protein which belongs to theG-protein coupled receptor 2 family. PTH1R is expressed in most tissues. It is most abundant in kidney, bone and liver. PTH1R is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. In bone, PTH1R is expressed on the surface of osteoblasts. When the receptor is activated, these cells in turn stimulate osteoclasts to ultimately increase the resorption rate. PTH1R is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of PTH1R is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), enchondromatosis multiple (ENCHOM), Eiken skeletal dysplasia (EISD) and primary failure of tooth eruption (PFE).