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This is a purified mouse anti-human Platelet Glycoprotein 4 Monoclonal Antibody that can be used in the validated applications of Western blot, ELISA and Immunhistochemistry. This Platelet Glycoprotein 4 Monoclonal Antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant human Platelet Glycoprotein 4. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Antibody characteristics include:
Applications: This Platelet Glycoprotein 4 Monoclonal Antibody has been validated for use in Western blot, ELISA and immunohistochemistry Host species and isotype: This is a mouse Monoclonal IgG1 against human Platelet Glycoprotein 4 Clone ID of monoclonal antibody (mAb): The Platelet Glycoprotein 4 monoclonal antibody clone ID is 1B9A5D3 Immunogen: Recombinant human Platelet Glycoprotein 4 protein Product size: 100 µg
Platelet glycoprotein 4, also known as Leukocyte differentiation antigen CD36, GPIIIB, GP3B, FAT, and CD36, is integral membrane proteinfound on the surface of many cell types in vertebrate animals. It belongs to theCD36 family and is found on platelets, erythrocytes, monocytes, differentiated adipocytes, mammary epithelial cells, spleen cells and some skin microdermal endothelial cells. CD36 has also been implicated in hemostasis, thrombosis, malaria, inflammation, lipid metabolism andatherogenesis. CD36 seems to have numerous potential physiological functions. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and binds long chain fatty acids. CD36 may also function as a cell adhesion molecule and in the transport and/or as a regulator of fatty acid transport. Defects in CD36 are the cause of platelet glycoprotein IV deficiencyalso known as CD36 deficiency. As a receptor for thrombospondin 1, CD36 plays a role in the regulation of angiogenesis, which may be a therapeutic strategy for controlling the dissemination of malignant neoplasms.