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This is a purified rabbit anti-human RRM2B Polyclonal Antibody, that can be used in the validated applications of ELISA, and immunohistochemistry. This RRM2B Polyclonal Antibody was produced in rabbits immunized with purified, recombinant human RRM2B. RRM2B specific IgG was purified by human RRM2B affinity chromatograpy.
Antibody characteristics include:
Applications: This RRM2B Polyclonal Antibody, has been validated for use in ELISA, and immunohistochemistry Host species and isotype: This is a rabbit Polyclonal IgG against human RRM2B Immunogen: Recombinant human RRM2B protein Product size: 100 µg
Ribonucleoside reductase subunit M2B (also known as RRM2B or p53R2) is an enzyme belonging to the iron-dependent ribonucleotide reductase (RNR) enzyme family which is essential for DNA synthesis. Ribonucleotide reductase (RNR) is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides and plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. Using in vivo 32P-orthophosphate labeling, it has been observed that 32P can be incorporated into RRM2B/p53R2 induced by UV irradiation, suggesting that p53R2 is a phosphorylated protein. It is hypothesized that p53R2 activity can be regulated at the posttranslational level in response to DNA damage. p53R2 has previously been shown to be essential for the maintenance of mtDNA copy number and its candidacy for tumor suppression has been evaluated in several mutational analyses of different cancer types. However, the contribution of p53R2 to the DNA damage response has been questioned because its transcriptional induction upon DNA damage is not rapid enough for prompt DNA repair. Instead, ATM-mediated phosphorylation has been suggested to regulate the DNA repair activity of p53R2 posttranslationally. In addition, a defect in p53R2 can induce a mild muscle disease of adult onset through disturbance of mitochondrial homeostasis but that this defect does not appear to be oncogenic.