This is a purified rabbit anti-human S100A12 Polyclonal Antibody, that can be used in the validated applications of Western blot, ELISA, and immunohistochemistry. This S100A12 Polyclonal Antibody was produced in rabbits immunized with purified, human cell-derived, recombinant human S100A12. S100A12 specific IgG was purified by human Cystatin A affinity chromatograpy.
Antibody characteristics include:
Applications: This S100A12 Polyclonal Antibody, has been validated for use in Western blot, ELISA, and immunohistochemistry
Host species and isotype: This is a rabbit Polyclonal IgG against human S100A12A
Immunogen: Recombinant human S100A12 protein
Product size: 100 µg
S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A12, also known as S100 calcium-binding protein A12, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, and S100A12, is a member of the S-101 family. Like the majority of S100 proteins, S100A12 is a dimer, with the interface between the two subunits being composed mostly of hydrophobic residues. The fold of S100A12 is similar to the other known crystal and solution structures of S100 proteins, except for the linker region between the two EF-hand motifs. S100A12 plays an important role in the inflammatory response.