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This is a purified rabbit anti-human Granzyme B Polyclonal Antibody, that can be used in the validated applications of Western blot, ELISA, and immunohistochemistry. This Granzyme B Polyclonal Antibody was produced in rabbits immunized with purified, human cell-derived, recombinant human Granzyme B. Granzyme B specific IgG was purified by human Granzyme B affinity chromatograpy.
Antibody characteristics include:
Applications: This Granzyme B Polyclonal Antibody, has been validated for use in Western blot, ELISA, and immunohistochemistry Host species and isotype: This is a rabbit Polyclonal IgG against human Granzyme B Immunogen: Recombinant human Granzyme B protein Product size: 100 µg
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 30 substrates of Granzyme B have been identified including the key substrate caspase-3, ICAD and Bid. Granzyme B is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells, and accordingly plays an essential role in immunosurveillance.