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This is a purified mouse anti-human IFNAR2 Monoclonal Antibody, FITC conjugate, that can be used in the validated application of flow cytometry. This IFNAR2 Monoclonal Antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant human IFNAR2, and conjugated with PE under optimum conditions. The unreacted FITC was removed.
Antibody characteristics include:
Applications: This IFNAR2 Monoclonal Antibody has been validated for use in flow cytometry Host species and isotype: This is a mouse Monoclonal IgG1 against human IFNAR2 Clone ID of monoclonal antibody (mAb): The IFNAR2 monoclonal antibody clone ID is 07 Immunogen: Recombinant human IFNAR2 protein Product size: 100 Tests
As described by NCBI, Interferon alpha/beta receptor 2, also known as IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNAR2 and IFNABR, is a single-pass type I membrane protein which belongs to thetype II cytokine receptor family. IFNAR2 is a receptor for interferons alpha and beta. IFNAR2 was detected in most lymphocytes, monocytes, and granulocytes, although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. The intra- and interdaily variations of IFNAR2 in lymphocytes, monocytes, and granulocytes were small. Among the lymphocyte subsets, IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity. Defects in IFNAR2 are associated with susceptibility to hepatitis B virus infection (HBV infection). Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.