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This is a purified rabbit anti-human Cyclin-E1 Polyclonal Antibody, that can be used in the validated applications of Western blot, ELISA, and immunohistochemistry. This Cyclin-E1 Polyclonal Antibody was produced in rabbits immunized with purified, recombinant human Cyclin-E1. Cyclin-E1 specific IgG was purified by human Cyclin-E1 affinity chromatograpy.
Antibody characteristics include:
Applications: This Cyclin-E1 Polyclonal Antibody, has been validated for use in Western blot, ELISA, and immunohistochemistry Host species and isotype: This is a rabbit Polyclonal IgG against human Cyclin-E1 Immunogen: Recombinant human Cyclin-E1 protein Product size: 100 µg
As described by NCBI, G1 / S-specific cyclin-E1, also known as CCNE1 and CCNE, is a nucleus protein which belongs to the cyclin family and Cyclin E subfamily. CCNE1 is highly expressed in testis and placenta, and is expressed at low levels in bronchial epithelial cells. As a positive regulator of the cell cycle, CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. In numerous human tumors, CCNE1 expression is frequently dysregulated, while the mechanism leading to its dysregulation remains incompletely defined. CCNE1 interacts with a member of the CDK2 / CDK protein kinases to form a serine / threonine kinase holoenzyme complex, including CDK2, CABLES1 and CCNA1, and the cyclin subunit of CCNE1 imparts substrate specificity to the complex. It interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. CCNE1 is also a potential therapeutic target in ovarian cancer. CCNE1-targeted therapy may benefit ovarian cancer patients with CCNE1 amplification.