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This is a purified rabbit anti-mouse CXADR Polyclonal Antibody, that can be used in the validated applications of Western blot, ELISA, and immunohistochemistry. This CXADR Polyclonal Antibody was produced in rabbits immunized with purified, recombinant mouse CXADR. CXADR specific IgG was purified by mouse CXADR affinity chromatograpy.
Antibody characteristics include:
Applications: This CXADR Polyclonal Antibody, has been validated for use in Western blot, ELISA, and immunohistochemistry Host species and isotype: This is a rabbit Polyclonal IgG against mouse CXADR Immunogen: Recombinant mouse CXADR protein Product size: 100 µg
CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a 46 kDa type I transmembrane glycoprotein expressed on the basolateralsurface, and belongs to the CTX family of the Ig superfamily. It is a receptor for group B coxsackieviruses and subgroup C adenoviruses and also acts as a homophilic adhesion molecule within junctional complexes, notably between epithelial cells lining body cavities and within myocardial intercalated discs. CXADR structrually comprises two extracellular immunoglobulin domains, a transmembrane helix and a C-terminal intracellular domain. The N-terminal Ig domain (D1) of CXADR is necessary and sufficient for adenovirus binding. The C-terminus interacts with several cytoplasmic junctional proteins, microtubules and the actin cytoskeleton. Pairs of transmembrane domains of CXADR associate with each other in a detergent cloud that mimics a cellular plasma membrane. Variants of CXADR areattached to the cell membrane by a GPI-anchor.