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This is a purified mouse anti-human CD66c Monoclonal Antibody, FITC conjugate, that can be used in the validated application of flow cytometry. This CD66c Monoclonal Antibody was obtained from a rabbit immunized with purified, recombinant human CD66c , and conjugated with FITC under optimum conditions. The unreacted FITC was removed.
Antibody characteristics include:
Applications: This CD66c Monoclonal Antibody has been validated for use in flow cytometry Host species and isotype: This is a rabbit Monoclonal IgG against human CD66c Clone ID of monoclonal antibody (mAb): The CD66c monoclonal antibody clone ID is 408 Immunogen: Recombinant human CD66c protein Product size: 100 Tests
As described by NCBI, Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. human CEACAMs include type I transmembrane proteins (CEACAM-1, -3, and -4) and GPI-linked molecules (CEACAM- 5 through -8). There is no human CEACAM-2. human CEACAM6 is a 90 kDa GPI-linked membrane protein consisting of a 34 aa signal sequence, a 286 aa extracellular domain (ECD) containing one N-terminal V-type Ig-like domain and two C2-type Ig-like domains., and a 24 aa hydrophobic C-terminal propeptide. The GPI membrane anchor is attached at the C-terminus following cleavage of the propeptide. CEACAM-6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.