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This is a purified mouse anti-human CD66e Monoclonal Antibody that can be used in the validated applications of ELISA and immunohistochemistry. ThisCD66e Monoclonal Antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant human CD66e. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Antibody characteristics include:
Applications: This CD66e Monoclonal Antibody has been validated for use in ELISA and immunohistochemistry Host species and isotype: This is a mouse Monoclonal IgG2a against human CD66e Clone ID of monoclonal antibody (mAb): The CD66e monoclonal antibody clone ID is 2G6A10 Immunogen: Recombinant human CD66e protein Product size: 100 µg
As described by NCBI, CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domain and a GPI anchor, and exists as a homodimer. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.