This is a purified rabbit anti-mouse CD38 Polyclonal Antibody, that can be used in the validated applications of Western blot, ELISA, flow cytometry and immunohistochemistry. This CD38 Polyclonal Antibody was produced in rabbits immunized with purified, recombinant mouse CD38. CD38 specific IgG was purified by mouse CD38 affinity chromatograpy.
Antibody characteristics include:
Applications: This CD38 Polyclonal Antibody, has been validated for use in Western blot, ELISA, flow cytometry and immunohistochemistry
Host species and isotype: This is a rabbit Polyclonal IgG against mouse CD38
Immunogen: Recombinant mouse CD38 protein
Product size: 100 µg
As described by NCBI, mouse CD38, also known as ADP-ribosyl cyclase, is a transmembrane glycoprotein comprising two to four N-linked oligosaccharide chains containing sialic acid residues. It is expressed on the surface of immune cells including CD4+, CD8+, B and natural killer cells. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. CD38 functions in cell adhesion, signal transduction and calcium signaling. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic β cells. CD38 has a key role in neuropeptide release, thereby critically regulating maternal and social behaviours, and may be an element in neurodevelopmental disorders. Defects of CD38 is associated with impaired immune responses, metabolic disturbances, and behavioral modifications, and has been connected to human immunodeficiency virus (HIV) infection, leukemias, myelomas, solid tumors, type I I diabetes mellitus and bone metabolism, as well as some genetically determined conditions. In addition, it was demonstrated that CD38 not only acts as a key modulator of the immune response, but also plays an equally important role as an intrinsic pulmonary component. CD38 as the main cellular NADase in mammalian tissues, and the characterization of its role on the control of cellular NAD levels indicate that CD38 may serve as a pharmacological target for multiple conditions.