This is a purified rabbit anti-human CD147 Monoclonal Antibody, Recombinant, that can be used in the validated applications of Western blot, ELISA, immunohistochemistry, and immunocytochemistry. This CD147 Monoclonal Antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human CD147.
Antibody characteristics include:
Applications: This CD147 Monoclonal Antibody, Recombinant, has been validated for use in Western blot, ELISA, immunohistochemistry, and immunocytochemistry
Host species and isotype: This is a rabbit Monoclonal IgG against human CD147
Clone ID of monoclonal antibody (mAb): The CD147 monoclonal antibody clone ID is 125
Immunogen: Recombinant human CD147 protein
Product size: 100 µg
As described by NCBI, CD147, also known as Basigin, BSG, and EMMPRIN, is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. CD147 is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation, and tumor progression. Enriched on the plasma memebrane of many human cancer (breast cancer, lymphoma, oral squamous cell carcinoma, glioma, melanoma, lung, bladder and kidney carcinomas ) cells, CD147 induces the production and release of matrix metalloproteinases in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction.