|TCRγδ, Armenian hamster IgG|
|Alexa Fluor® 488 dye|
Ex/Em and laser configuration:
|488/519 nm, blue laser|
Leukocyte Workshop Status:
Specificity for TCRγδ
This Armenian hamster IgG is specific to the γδ T-cell receptor (TCR) complex. The TCRγδ heterodimer of the CD3/T-cell receptor complex is clonotypic and consists of Ig-like variable and constant domains. It is expressed during thymopoiesis and on the small subpopulation of γδ TCR-expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial tissues are γδ+ and have limited receptor diversity. The TCRγδ heterodimer recognizes peptide antigen bound to MHC antigens, and subsequent signal transduction mediated by the invariant chains leads to T cell activation. The monoclonal antibody UC7-13D5 is specific for the γδ heterodimer and plate-bound UC7-13D5 activates γδ TCR-bearing cells. This antibody does not react with αβ TCR-expressing T cells.
For the full list of all TCRγδ antibodies available, please visit the primary antibody search tool.
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