|CD45.1/Ly-5.1, mouse IgG2aκ monoclonal|
Ex/Em and laser configuration:
|600-650/767 nm, red laser|
Leukocyte Workshop Status:
Specificity for CD45.1/Ly-5.1
This antibody detects mouse C45.1 (Leukocyte Common Antigen). The CD45 antigen is an essential regulator of leukocyte activation and development, and is now known to be a protein tyrosine phosphatase, e.g. CD45 is able to dephosphorylate the Src family of protein kinases. Thisactivity is now known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling and Fc receptor stimulation. The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms, such as the restricted variants and as allelic forms CD45.1/Ly-5.1 and CD45.2/Ly-5.2. The former arises as a result of alternative splicing of different exons. The specificity of antibodies to CD45.1 and CD45.2 hasbeen exploited in studies where resolution of donor and recipient cells is essential, such as in gene therapy or bone marrow transplantation. The monoclonal antibody A20 recognizes all mouse leukocytes expressing the CD45.1 allotype.
For the full list of all CD45.1 antibodies available, please visit the primary antibody search tool.
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