|CD45RB, mouse IgG1|
Ex/Em and laser configuration:
|650/660 nm, red laser|
Leukocyte Workshop Status:
Specificity for CD45RB
CD45RB is a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RB is expressed e.g. in microglia and inflammatory cells.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
For the full list of all CD45RB; antibodies available, please visit the primary antibody search tool.
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