• Validated in Western Blot and indirect ELISA
• Isotype: Rabbit IgG
• Concentration: 0.5 mg⁄ml
• Buffer: Phosphate-buffered saline (PBS) with 0.09% sodium azide
Oligoclonal Antibodies—Exceptional Consistency Helps Save Time and Money
Invitrogen's oligoclonal antibodies are a pool of monoclonal rabbit IgG antibodies targeted against a specific antigen. Oligoclonal antibodies are produced by transfection of mammalian cells with heavy and light chain antibody cDNAs. This provides you with the highest consistency between lots, eliminating the need to revalidate your assays for each lot.
Oligoclonal Antibody Advantages Include:
• Superior lot-to-lot consistency
• Extremely high specificity and sensitivity
• Validation by Invitrogen
Specific for IL-I beta
IL-1 beta is a pro-inflammatory cytokine produced by monocytes and activated macrophages. The pro IL-1b is processed to its active form by Caspase 1 (1). IL-1b is one of the most well studied interleukin 1 cytokine family members as it plays an important role in mediating auto-inflammatory diseases. It is involved in inflammatory response, activates COX2 leading to inflammatory hypersensitivity. It is also involved in proliferation, differentiation and apoptosis of cells. It induces IL-2 release, B cell maturation and proliferation and Thymocyte proliferation.
Obtain More Reliable Data
The proprietary recombinant technology employed in the production of Invitrogen’s oligoclonal antibodies means you are assured of the greatest degree of reliability. Staining of nonspecific proteins is virtually eliminated while very high sensitivity is achieved.
Detect Low Levels of Target Protein
Invitrogen's oligoclonal antibodies demonstrate much higher sensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of your precious samples than with ordinary antibodies.
IL1Beta mouse ABfinity Recombinant Rabbit IgG—Use Like Any Other IgG Antibody
As with traditional IgG antibodies, gel electrophoresis of rabbit oligoclonal antibodies produces a 150 kDa band under non-reducing conditions and 50 kDa and 25 kDa bands under reducing conditions.
For research use only. Not intended for any animal or human therapeutic or diagnostic use.
Rapidly Locate the Antibody You Need Using the Antibody Search Tool
- Lopez-Castejon G, Brough D. Cytokine & Growth Factor Reviews. 2011 Aug, 22(4);189-195, PMID: 22019906 .