Product References
Signal transducer and activator of transcription (STAT) 1 and STAT3 are expressed in the human ovary and have Janus kinase 1-independent functions in the COV434 human granulosa cell line.
Reproduction, fertility, and development
Frost ER,Ford EA,Peters AE,Reed NL,McLaughlin EA,Baker MA,Lovell-Badge R,Sutherland JM
33-3400 was used in Western Blotting to implicate a conserved role for JAK/STAT signalling in human ovary development, warranting further investigation of this pathway in human granulosa cell function.
Sat Aug 01 00:00:00 EDT 2020
PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma.
Nature communications
Liu XD,Kong W,Peterson CB,McGrail DJ,Hoang A,Zhang X,Lam T,Pilie PG,Zhu H,Beckermann KE,Haake SM,Isgandrova S,Martinez-Moczygemba M,Sahni N,Tannir NM,Lin SY,Rathmell WK,Jonasch E
33-3400 was used in Western Blotting to investigate if PBRM1/Pbrm1 deficiency can reduce the binding of brahma-related gene 1 (BRG1) to the IFNγ receptor 2 (Ifngr2) promoter, thus decreasing STAT1 phosphorylation and the subsequent expression of IFNγ target genes.
Fri May 01 00:00:00 EDT 2020
PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma.
Nature communications
Liu XD,Kong W,Peterson CB,McGrail DJ,Hoang A,Zhang X,Lam T,Pilie PG,Zhu H,Beckermann KE,Haake SM,Isgandrova S,Martinez-Moczygemba M,Sahni N,Tannir NM,Lin SY,Rathmell WK,Jonasch E
33-3400 was used in Western Blotting to investigate if PBRM1/Pbrm1 deficiency can reduce the binding of brahma-related gene 1 (BRG1) to the IFNγ receptor 2 (Ifngr2) promoter, thus decreasing STAT1 phosphorylation and the subsequent expression of IFNγ target genes.
Fri May 01 00:00:00 EDT 2020
Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture.
Molecular vision
Keller KE,Yang YF,Sun YY,Walter MR,Wirtz MK
Published figure using Phospho-STAT1 (Tyr701) monoclonal antibody (Product # 33-3400) in Western Blot
Wed Apr 22 00:00:00 EDT 2020
TWEAK blockade decreases atherosclerotic lesion size and progression through suppression of STAT1 signaling in diabetic mice.
Scientific reports
Fernández-Laso V,Sastre C,Méndez-Barbero N,Egido J,Martín-Ventura JL,Gómez-Guerrero C,Blanco-Colio LM
33-3400 was used in Western Blotting to demonstrate that TWEAK blockade delay plaque progression and alter plaque composition in diabetic atherosclerotic mice.
Thu Apr 27 00:00:00 EDT 2017
TWEAK blockade decreases atherosclerotic lesion size and progression through suppression of STAT1 signaling in diabetic mice.
Scientific reports
Fernández-Laso V,Sastre C,Méndez-Barbero N,Egido J,Martín-Ventura JL,Gómez-Guerrero C,Blanco-Colio LM
33-3400 was used in Western Blotting to demonstrate that TWEAK blockade delay plaque progression and alter plaque composition in diabetic atherosclerotic mice.
Thu Apr 27 00:00:00 EDT 2017
Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2.
PLoS pathogens
Stuart JH,Sumner RP,Lu Y,Snowden JS,Smith GL
Published figure using Phospho-STAT1 (Tyr701) monoclonal antibody (Product # 33-3400) in Western Blot
Thu Dec 01 00:00:00 EST 2016
Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2.
PLoS pathogens
Stuart JH,Sumner RP,Lu Y,Snowden JS,Smith GL
Published figure using Phospho-STAT1 (Tyr701) monoclonal antibody (Product # 33-3400) in Western Blot
Thu Dec 01 00:00:00 EST 2016
PDGFRβ signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis.
Nature communications
He C,Medley SC,Hu T,Hinsdale ME,Lupu F,Virmani R,Olson LE
Published figure using Phospho-STAT1 (Tyr701) monoclonal antibody (Product # 33-3400) in Western Blot
Fri Jul 17 00:00:00 EDT 2015
STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes.
Science signaling
Xiang M,Birkbak NJ,Vafaizadeh V,Walker SR,Yeh JE,Liu S,Kroll Y,Boldin M,Taganov K,Groner B,Richardson AL,Frank DA
33-3400 was used in western blot to identify an epigenetic mechanism of crosstalk between STAT3 and NF-κB that regulates constitutive STAT3 activation in oncogenesis.
Tue Jan 28 00:00:00 EST 2014
Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface.
Science (New York, N.Y.)
Nancy P,Tagliani E,Tay CS,Asp P,Levy DE,Erlebacher A
Fri Jun 08 00:00:00 EDT 2012
The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.
The Journal of clinical investigation
Marotta LL,Almendro V,Marusyk A,Shipitsin M,Schemme J,Walker SR,Bloushtain-Qimron N,Kim JJ,Choudhury SA,Maruyama R,Wu Z,Gönen M,Mulvey LA,Bessarabova MO,Huh SJ,Silver SJ,Kim SY,Park SY,Lee HE,Anderson KS,Richardson AL,Nikolskaya T,Nikolsky Y,Liu XS,Root DE,Hahn WC,Frank DA,Polyak K
33-3400 was used in Western Blotting to identify 15 genes required for cell growth and proliferation in CD44+CD24- human breast cancer cells.
Fri Jul 01 00:00:00 EDT 2011
PDlim2 selectively interacts with the PDZ binding motif of highly pathogenic avian H5N1 influenza A virus NS1.
PloS one
Yu J,Li X,Wang Y,Li B,Li H,Li Y,Zhou W,Zhang C,Wang Y,Rao Z,Bartlam M,Cao Y
Published figure using Phospho-STAT1 (Tyr701) monoclonal antibody (Product # 33-3400) in Western Blot
Mon Nov 28 00:00:00 EST 2011
IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities.
Journal of immunology (Baltimore, Md. : 1950)
Ho MY,Leu SJ,Sun GH,Tao MH,Tang SJ,Sun KH
Sun Nov 15 00:00:00 EST 2009
Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques.
PLoS pathogens
de Lang A,Baas T,Teal T,Leijten LM,Rain B,Osterhaus AD,Haagmans BL,Katze MG
Published figure using Phospho-STAT1 (Tyr701) monoclonal antibody (Product # 33-3400) in Immunohistochemistry
Fri Aug 10 00:00:00 EDT 2007
Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques.
PLoS pathogens
de Lang A,Baas T,Teal T,Leijten LM,Rain B,Osterhaus AD,Haagmans BL,Katze MG
Published figure using Phospho-STAT1 (Tyr701) monoclonal antibody (Product # 33-3400) in Immunohistochemistry
Fri Aug 10 00:00:00 EDT 2007
IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3.
Journal of immunology (Baltimore, Md. : 1950)
Albanesi C,Fairchild HR,Madonna S,Scarponi C,De Pità O,Leung DY,Howell MD
33-3400 was used in Western Blotting to suggest that targeting the STAT-1-signaling pathway or suppressor of cytokine signaling expression enhances beta-defensin expression and represents a new therapeutic strategy for reduction of infection in human diseases associated with beta-defensin deficiency.
Sun Jul 15 00:00:00 EDT 2007
Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.
The Journal of biological chemistry
Nelson EA,Walker SR,Li W,Liu XS,Frank DA
Published figure using Phospho-STAT1 (Tyr701) monoclonal antibody (Product # 33-3400) in Western Blot
Fri Sep 08 00:00:00 EDT 2006
Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.
The Journal of biological chemistry
Nelson EA,Walker SR,Li W,Liu XS,Frank DA
Published figure using Phospho-STAT1 (Tyr701) monoclonal antibody (Product # 33-3400) in Western Blot
Fri Sep 08 00:00:00 EDT 2006
Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways.
Molecular and cellular biology
Alblas J,Honing H,de Lavalette CR,Brown MH,Dijkstra CD,van den Berg TK
33-3400 was used in western blot to analyze the induction of macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways by signal regulatory protein alpha ligation
Mon Aug 01 00:00:00 EDT 2005
Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells.
The Journal of biological chemistry
Aksoy E,Zouain CS,Vanhoutte F,Fontaine J,Pavelka N,Thieblemont N,Willems F,Ricciardi-Castagnoli P,Goldman M,Capron M,Ryffel B,Trottein F
33-3400 was used in western blot to analyze activation of TLR3 in dendritic cells by double-stranded RNAs from the helminth parasite Schistosoma
Fri Jan 07 00:00:00 EST 2005
Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).
Oncogene
Duensing A,Medeiros F,McConarty B,Joseph NE,Panigrahy D,Singer S,Fletcher CD,Demetri GD,Fletcher JA
Thu May 13 00:00:00 EDT 2004
The protective effect of moderate hypothermia during intestinal ischemia-reperfusion is associated with modification of hepatic transcription factor activation.
Journal of pediatric surgery
Parkinson EJ,Townsend PA,Stephanou A,Latchman DS,Eaton S,Pierro A
33-3400 was used in western blot to study the mechanism of hypothermic protection during intestinal ischemia-reperfusion
Sat May 01 00:00:00 EDT 2004
Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas.
Cancer research
Nepomuceno RR,Balatoni CE,Natkunam Y,Snow AL,Krams SM,Martinez OM
33-3400 was used in western blot to report that rapamycin limits B-cell lymphoma growth while simultaneously providing immunosuppression to prevent graft rejection in patients and protection from EBV-associated post transplant lymphoproliferative disorder.
Fri Aug 01 00:00:00 EDT 2003
Constitutive activation of Jak/STAT proteins in Epstein-Barr virus-infected B-cell lines from patients with posttransplant lymphoproliferative disorder.
Transplantation
Nepomuceno RR,Snow AL,Robert Beatty P,Krams SM,Martinez OM
33-3400 was used in immunoprecipitation to investigate signaling pathways in posttransplant lymphoproliferative disease.
Thu Aug 15 00:00:00 EDT 2002
Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity.
The Journal of biological chemistry
Zhang Y,Turkson J,Carter-Su C,Smithgall T,Levitzki A,Kraker A,Krolewski JJ,Medveczky P,Jove R
Fri Aug 11 00:00:00 EDT 2000