Research indicates that genetic variations are key for understanding the genetic basis of complex traits and diseases. Variants can influence phenotypes, the susceptibility of an individual to disease, drug response and human genome evolution. Many SNPs have been associated with common disorders such as diabetes, obesity, and cardiovascular diseases. Further research into identifying the risk factors and understanding the biology of risk variants would enable a more complete view of these conditions and lead to improved disease treatment and prevention.
Studies indicate that the genetic variant located 10 kb upstream of the transcription start site of the INSIG2 gene is associated with obesity.
SNP near the Insulin-induced gene 2 (INSIG2)