β-2-Adrenergic Receptor

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  • Citations (1)

General Description

Research indicates that genetic variations are key for understanding the genetic basis of complex traits and diseases. Variants can influence phenotypes, the susceptibility of an individual to disease, drug response and human genome evolution. Many SNPs have been associated with common disorders such as diabetes, obesity, and cardiovascular diseases. Further research into identifying the risk factors and understanding the biology of risk variants would enable a more complete view of these conditions and lead to improved disease treatment and prevention.

Focus

Studies show that the Gln27Glu and Arg16Gly polymorphisms are markedly associated with obesity.

Target Disease/Application

β-2-Adrenergic Receptor

Assay ID Clinical Name Gene Symbol Gene Name dbSNP ID  
C___2084764_20 ADRB2 R16E ADRB2 β-2-adrenergic receptor rs1042713
C___2084765_20 ADRB2 Q27E ADRB2 β-2-adrenergic receptor rs1042714

Specifications

General Specifications

# of assays: 2
Technology: TaqMan® Assays
Intended Use: Research Use Only

Kit Storage

-20° C

 

Citations & References (1)

  • Human β-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte β-2 adrenoceptor function.

Authors
Large V, Hellström L, Reynisdottir S, Lönnqvist F, Eriksson P, Lannfelt L, Arner P.
Journal
J Clin Invest. (1997) 100:3005-13.