Transcription Factor 7-like 2 (T-cell specific, HMG-box)

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  • Citations (1)

General Description

Research indicates that genetic variations are key for understanding the genetic basis of complex traits and diseases. Variants can influence phenotypes, the susceptibility of an individual to disease, drug response and human genome evolution. Many SNPs have been associated with common disorders such as diabetes, obesity, and cardiovascular diseases. Further research into identifying the risk factors and understanding the biology of risk variants would enable a more complete view of these conditions and lead to improved disease treatment and prevention.

Focus

Polymorphisms in TCF7L2 are shown by research to be associated with Type 2 Diabetes.

Target Disease/Application

Transcription Factor 7-like 2 (T-cell specific, HMG-box)

Assay ID Clinical Name Gene Symbol Gene Name dbSNP ID  
C__29347861_10 TCF7L2 IVS3C>T TCF7L2 Transcription Factor 7-like 2 (T-cell specific, HMG-box) rs7903146
C____291484_20 TCF7L2 IVS4G>T TCF7L2 Transcription Factor 7-like 2 (T-cell specific, HMG-box) rs12255372

Specifications

General Specifications

# of assays: 2
Technology: TaqMan® Assays - Pre-formulated assay (20x or 60x mix)
Scale: Available in multiple scales
Intended Use: Research Use Only
 

Citations & References (1)

  • Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis.

Authors
Tong Y, et.al
Journal
BMC Med Genet. (2009) 19:15.