CBFB-MYH11 Fusion Transcripts Panel

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Research Focus

Reserach investigations have shown that inv(16)(p13q22) rearrangement is present in approximately 10% of cases with de novo acute myeloid leukemia (AML) and results in a CBFB-MYH11 gene fusion. Furthermore this gene fusion has been used in cinincal research studies for the subclassification of AML as well as for the prognostic potential. Outcomes have suggested that subjects with this fusion gene define a specific subgroup with a relatively good prognosis.

Target Disease/Application

Acute myeloid leukemia (AML)

Chromosomal Alteration

inv(16)(p13q22)

Assay ID Clinical Name Gene Symbol Gene Aliases Amplicon Length  
Hs03043618_ft CBF/MYH11 (A) CBFB-MYH11 CBFB MYH11 77
Hs03043615_ft CBF/MYH11 (D) CBFB-MYH11 CBFB MYH11 69
Hs03460064_ft CBF/MYH11 (E) CBFB-MYH11 CBFB MYH11 137

Specifications

General Specifications

# of assays: 3
Technology: TaqMan® Assays - Pre-formulated assay (20x or 60x mix)
Scale: Available in multiple scales
Intended Use: Research Use Only

Kit Storage

-20° C

Documents

Product Literature