XRCC3 T241M (T/C)

  • Product Reviews (0)
  • Citations (2)

Research Focus

Reduced DNA repair capacity resulting from genetic polymorphisms of various DNA repair genes has been shown in clinincal research to be associated with improved survival with platinum-based chemotherapy. Reduced efficacy of the XRCC3 protein, a consequence of the polymorphic variant, may result in impaired ability to repair cisplatin DNA damage.

Target Disease/Application

DNA repair genes polymorphisms

Mutation

T/C M241T

Assay ID dbSNP ID SNP Name Gene Symbol Gene Name SNP Type  
C___8901525_10 rs861539 XRCC3 T241M XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 Mis-sense Mutation
KLC1 kinesin light chain 1 Intron, Mis-sense Mutation, Transition Substitution

Specifications

General Specifications

# of assays: 1
Technology: TaqMan® Assays - Pre-formulated assay (20x or 60x mix)
Scale: Available in multiple scales
Intended Use: Research Use Only

Kit Storage

-20° C

 

Citations & References (2)

  • XPD and XRCC1 Genetic Polymorphisms Are Prognostic Factors in Advanced Non—Small-Cell Lung Cancer Patients Treated With Platinum Chemotherapy

Authors
Sarada Gurubhagavatula et al.
Journal
Journal of Clinical Oncology, Vol 22, No 13 (July 1), 2004: pp. 2594-2601
  • Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients

Authors
de las Penas et al.
Journal
Annals of Oncology 17: 668–675, 2006 R.