Product References
The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea.
Proceedings of the National Academy of Sciences of the United States of America
Golden EJ,Benito-Gonzalez A,Doetzlhofer A
MA5-12835 was used in immunohistochemistry to elucidate the molecular mechanisms involved in the timing and coordination of auditory prosensory proliferation and differentiation.
Tue Jul 21 00:00:00 EDT 2015
Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway.
Carcinogenesis
Shukla S,Bhaskaran N,Babcook MA,Fu P,Maclennan GT,Gupta S
MA5-12835 was used in immunoprecipitation and western blot to study the role of PI3 kinase/Akt/FoxO signaling in the mechanism by which apigenin inhibits the progression of prostate cancer in a murine model
Sat Feb 01 00:00:00 EST 2014
Recruitment of trimeric proliferating cell nuclear antigen by G1-phase cyclin-dependent kinases following DNA damage with platinum-based antitumour agents.
British journal of cancer
He G,Kuang J,Koomen J,Kobayashi R,Khokhar AR,Siddik ZH
MA5-12835 was used in western blot to study the role of trimeric PCNA recruited to G1-phase Cdk-p21 complexes following platinum-induced DNA damage
Tue Oct 29 00:00:00 EDT 2013
MiR-223 suppresses cell proliferation by targeting IGF-1R.
PloS one
Jia CY,Li HH,Zhu XC,Dong YW,Fu D,Zhao QL,Wu W,Wu XZ
MA5-12835 was used in western blot to study the mechanism by which microRNA-223 attenuates cell proliferation
Mon Mar 26 00:00:00 EDT 2012
Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells.
Journal of pediatric gastroenterology and nutrition
Nguyen KD,Blain SW,Gress F,Treem WR
MA5-12835 was used in immunocytochemistry to study the role of inflammatory mediators of esophagitis in altered p27(Kip1) expression in esophageal epithelial cells
Mon Nov 01 00:00:00 EDT 2010
Upregulation of TNF receptor type 2 in human and experimental renal allograft rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Hoffmann U,Bergler T,Rihm M,Pace C,Krüger B,Rümmele P,Stoelcker B,Banas B,Männel DN,Krämer BK
MA5-12835 was used in immunohistochemistry to study the expression and potential role of TNFR2 in human and experimental renal allograft rejection
Wed Apr 01 00:00:00 EDT 2009
Presence of HER4 associates with increased sensitivity to Herceptin in patients with metastatic breast cancer.
Breast cancer research : BCR
Sassen A,Diermeier-Daucher S,Sieben M,Ortmann O,Hofstaedter F,Schwarz S,Brockhoff G
MA5-12835 was used in immunohistochemistry to investigate the mechanism for cellular susceptibility to Herceptin
Wed Feb 24 00:00:00 EST 2010
Penta-O-galloyl-beta-D-glucose induces S- and G(1)-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1.
Carcinogenesis
Hu H,Zhang J,Lee HJ,Kim SH,Lü J
MA5-12835 was used in western blot to examine the effect of penta-O-galloyl-beta-D-glucose on prostate cancer cell proliferation
Fri May 01 00:00:00 EDT 2009
Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis.
Acta biochimica et biophysica Sinica
Zhang W,Zeng Z,Zhou Y,Xiong W,Fan S,Xiao L,Huang D,Li Z,Li D,Wu M,Li X,Shen S,Wang R,Cao L,Tang K,Li G
MA5-12835 was used in immunohistochemistry to study aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma
Fri May 01 00:00:00 EDT 2009
BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer.
Cancer research
Xia W,Nagase S,Montia AG,Kalachikov SM,Keniry M,Su T,Memeo L,Hibshoosh H,Parsons R
MA5-12835 was used in western blot to study the role of BAF180 in regulating p21 expression in breast cancer
Sat Mar 15 00:00:00 EDT 2008
Evaluation of the value of frozen tissue section used as "gold standard" for immunohistochemistry.
American journal of clinical pathology
Shi SR,Liu C,Pootrakul L,Tang L,Young A,Chen R,Cote RJ,Taylor CR
MA5-12835 was used in immunohistochemistry to evaluate different fixation and antigen retrieval methods for immmunohistochemical studies on frozen tissues
Sat Mar 01 00:00:00 EST 2008
Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity.
Molecular and cellular biology
James MK,Ray A,Leznova D,Blain SW
MA5-12835 was used in immunoprecipitation to study if the growth state-dependent tyrosine phosphorylation of p27Kip1 determines whether or not it inhibits cdk4
Tue Jan 01 00:00:00 EST 2008
Activated Akt as an indicator of prognosis in gastric cancer.
Virchows Archiv : an international journal of pathology
Cinti C,Vindigni C,Zamparelli A,La Sala D,Epistolato MC,Marrelli D,Cevenini G,Tosi P
MA5-12835 was used in immunohistochemistry to examine the prognostic significance of activated AKT in gastric cancer
Sat Nov 01 00:00:00 EDT 2008
The combination of high cyclin E and Skp2 expression in breast cancer is associated with a poor prognosis and the basal phenotype.
Human pathology
Voduc D,Nielsen TO,Cheang MC,Foulkes WD
MA5-12835 was used in immunohistochemistry to study the prognostic value of high expression of both cyclin E and Skp2 in basal phenotype breast cancer
Wed Oct 01 00:00:00 EDT 2008
Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene.
Intervirology
Ye L,Dong N,Wang Q,Xu Z,Cai N,Wang H,Zhang X
MA5-12835 was used in western blot to study the molecular mechanism of hepatocellular carcinoma development induced by hepatitis B virus X protein
Fri Apr 18 00:00:00 EDT 2008
Expression of senescence-related genes in human corneal endothelial cells.
Molecular vision
Song Z,Wang Y,Xie L,Zang X,Yin H
MA5-12835 was used in immunohistochemistry to study the expression of senescence-related genes in human corneal endothelial cells from donors of different ages
Tue Jan 29 00:00:00 EST 2008
Increased SKP2 and CKS1 gene expression contributes to the progression of human urothelial carcinoma.
The Journal of urology
Kawakami K,Enokida H,Tachiwada T,Nishiyama K,Seki N,Nakagawa M
MA5-12835 was used in immunohistochemistry to study the role of SKP2 and CKS1 in the progression of human urothelial carcinoma
Sun Jul 01 00:00:00 EDT 2007
Antitumor activity of CTFB, a novel anticancer agent, is associated with the down-regulation of nuclear factor-kappaB expression and proteasome activation in head and neck squamous carcinoma cell lines.
Molecular cancer therapeutics
Skvortsov S,Skvortsova I,Stasyk T,Schiefermeier N,Neher A,Gunkel AR,Bonn GK,Huber LA,Lukas P,Pleiman CM,Zwierzina H
MA5-12835 was used in western blot to investigate the mechanism for the antitumor activity of 5-Chloro-N-[2-[2-(4-chloro-phenyl)-3-methyl-butoxy]-5-trifluoromethyl-phenyl]-2-hydroxy-benzamide in head and neck cancer cell lines
Fri Jun 01 00:00:00 EDT 2007
Disruption of heparan and chondroitin sulfate signaling enhances mesenchymal stem cell-derived osteogenic differentiation via bone morphogenetic protein signaling pathways.
Stem cells (Dayton, Ohio)
Manton KJ,Leong DF,Cool SM,Nurcombe V
MA5-12835 was used in western blot to study the role of heparan and chondroitin sulfate signaling in the osteogenic differentiation of mesenchymal stem cells
Thu Nov 01 00:00:00 EDT 2007
Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells.
The Journal of pharmacology and experimental therapeutics
Wiseman DA,Werner SR,Crowell PL
MA5-12835 was used in western blot to study the role of p21(Cip1) and p27(Kip1) in the induction of cell cycle arrest in human panceatic adenocarcinoma cells by isoprenoids
Thu Mar 01 00:00:00 EST 2007
Increased expression of CCAAT/enhancer-binding protein beta in proliferative inflammatory atrophy of the prostate: relation with the expression of COX-2, the androgen receptor, and presence of focal chronic inflammation.
The Prostate
Wang W,Bergh A,Damber JE
MA5-12835 was used in immunohistochemistry to study the mechanisms driving increased expression of C/EBPbeta in proliferative inflammatory atrophy of the prostate
Wed Aug 01 00:00:00 EDT 2007
Prognostic implications of cyclin B1, p34cdc2, p27(Kip1) and p53 expression in gastric cancer.
Yonsei medical journal
Kim DH
MA5-12835 was used in immunohistochemistry to study the prognostic significance of the expression of cyclin B1, p34cdc2, p27(Kip1) and p53 in gastric cancer
Fri Aug 31 00:00:00 EDT 2007
Iressa induces cytostasis and augments Fas-mediated apoptosis in acinic cell adenocarcinoma overexpressing HER2/neu.
International journal of cancer
Piechocki MP,Yoo GH,Dibbley SK,Amjad EH,Lonardo F
MA5-12835 was used in western blot to study the mechanism by which Iressa induces cytostasis and augments Fas-mediated apoptosis in acinic cell adenocarcinoma
Sat Jul 15 00:00:00 EDT 2006
E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells.
Molecular and cellular biology
Rothschild G,Zhao X,Iavarone A,Lasorella A
MA5-12835 was used in western blot to study the role of E-protein transcription factors and Id2 in cell cycle regulation in neural cells
Thu Jun 01 00:00:00 EDT 2006
N-all-trans-retinoyl-L-proline inhibits metastatic potential of hepatocellular carcinoma cells.
Cell biology international
Wu XZ,Shi PC,Hu P,Chen Y,Ding SS
MA5-12835 was used in western blot to examine the therapeutic effect of N-all-trans-retinoyl-L-proline in the metastasis of hepatocellular carcinoma cells
Tue Aug 01 00:00:00 EDT 2006
Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea.
Brain research
Doetzlhofer A,White P,Lee YS,Groves A,Segil N
MA5-12835 was used in immunohistochemistry to investigate the progenitors of hair cells and supporting cells from embryonic mouse cochlea
Fri May 26 00:00:00 EDT 2006
Suppressor of cytokine signalling 2 (SOCS-2) expression in breast carcinoma.
Journal of clinical pathology
Farabegoli F,Ceccarelli C,Santini D,Taffurelli M
MA5-12835 was used in immunohistochemistry to study SOCS2 expression and survival in breast carcinoma
Sat Oct 01 00:00:00 EDT 2005
Increase in Ara-C cytotoxicity in the presence of valproate, a histone deacetylase inhibitor, is associated with the concurrent expression of cyclin D1 and p27(Kip 1) in acute myeloblastic leukemia cells.
Leukemia research
Siitonen T,Koistinen P,Savolainen ER
MA5-12835 was used in western blot to investigate the effect of valproate on Ara-C cytotoxicity in acute myeloblastic leukemia cells and its mechanism
Tue Nov 01 00:00:00 EST 2005
Expression of p8 protein in breast carcinoma; an inverse relationship with apoptosis.
Anticancer research
Ito Y,Yoshida H,Motoo Y,Iovanna JL,Nakamura Y,Kakudo K,Uruno T,Takamura Y,Miya A,Noguchi S,Kuma K,Miyauchi A
MA5-12835 was used in immunohistochemistry to study the expression of p8 protein in breast carcinoma and its relationship with apoptosis
Thu Jun 09 00:00:00 EDT 2005
An in vivo evaluation of docetaxel delivered intratumorally in head and neck squamous cell carcinoma.
Archives of otolaryngology--head & neck surgery
Yoo GH,Subramanian G,Boinpally RR,Iskander A,Shehadeh N,Oliver J,Ezzat W,Piechocki MP,Ensley JF,Lin HS,Shibuya TY,Polin L,Parchment RE
MA5-12835 was used in western blot to study the mechanisms of action of intra-tumoral docetaxel in head and neck squamous cell carcinoma
Sun May 01 00:00:00 EDT 2005
Downregulation of Bcl-2 by podocytes is associated with progressive glomerular injury and clinical indices of poor renal prognosis in human IgA nephropathy.
Journal of the American Society of Nephrology : JASN
Qiu LQ,Sinniah R,I-Hong Hsu S
MA5-12835 was used in immunohistochemistry to investigate the influence of Bcl-2 reduction on the progression and prognosis of human IgA nephropathy
Thu Jan 01 00:00:00 EST 2004
Predicting early failure after adjuvant chemotherapy in high-risk breast cancer patients with extensive lymph node involvement.
Clinical cancer research : an official journal of the American Association for Cancer Research
Faneyte IF,Peterse JL,Van Tinteren H,Pronk C,Bontenbal M,Beex LV,van der Wall E,Richel DJ,Nooij MA,Voest EE,Hupperets P,Ten Vergert EM,de Vries EG,Rodenhuis S,van de Vijver MJ
MA5-12835 was used in immunohistochemistry to study the relationship between early failure after adjuvant chemotherapy and poor survival in high-risk breast cancer
Thu Jul 01 00:00:00 EDT 2004
pRb2/p130, vascular endothelial growth factor, p27(KIP1), and proliferating cell nuclear antigen expression in hepatocellular carcinoma: their clinical significance.
Clinical cancer research : an official journal of the American Association for Cancer Research
Claudio PP,Russo G,Kumar CA,Minimo C,Farina A,Tutton S,Nuzzo G,Giuliante F,Angeloni G,Maria V,Vecchio FM,Campli CD,Giordano A
MA5-12835 was used in immunohistochemistry to study the expression of pRb2/p130, VEGF, p27(KIP1), and PCNA as potential markers of hepatocellular carcinoma
Sat May 15 00:00:00 EDT 2004
Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling.
Cancer research
Mallikarjuna G,Dhanalakshmi S,Singh RP,Agarwal C,Agarwal R
MA5-12835 was used in western blot to investigate the mechanism of photocarcinogenesis prevention by silibinin
Wed Sep 01 00:00:00 EDT 2004
Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers.
The Journal of pathology
Au NH,Cheang M,Huntsman DG,Yorida E,Coldman A,Elliott WM,Bebb G,Flint J,English J,Gilks CB,Grimes HL
MA5-12835 was used in immunohistochemistry to evaluate immunohistochemical markers of non-small cell lung cancer using unsupervised hierarchical clustering analysis
Wed Sep 01 00:00:00 EDT 2004
Simultaneous chromosome 1q gain and 16q loss is associated with steroid receptor presence and low proliferation in breast carcinoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Farabegoli F,Hermsen MA,Ceccarelli C,Santini D,Weiss MM,Meijer GA,van Diest PJ
MA5-12835 was used in immunohistochemistry to study the association of simultaneous chromosome 1q gain and 16q loss with low proliferation in breast carcinoma
Thu Apr 01 00:00:00 EST 2004
In vitro growth and differentiation of mammalian sensory hair cell progenitors: a requirement for EGF and periotic mesenchyme.
Developmental biology
Doetzlhofer A,White PM,Johnson JE,Segil N,Groves AK
MA5-12835 was used in immunocytochemistry to evaluate an invitro cell culture system for the study of mammalian sensory hair cell growth and differentiation
Sun Aug 15 00:00:00 EDT 2004
Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear.
The Journal of comparative neurology
Radde-Gallwitz K,Pan L,Gan L,Lin X,Segil N,Chen P
MA5-12835 was used in immunohistochemistry to study Islet1 expression as a marker of sensory and neuronal cell lineage in the mammalian inner ear
Mon Sep 27 00:00:00 EDT 2004
Significantly decreased P27 expression in endometrial carcinoma compared to complex hyperplasia with atypia (correlation with p53 expression).
Pathology oncology research : POR
Ozkara SK,Corakci A
MA5-12835 was used in immunohistochemistry to study p27 and p53 expression in endometrial carcinoma compared to complex hyperplasia with atypia
Thu Dec 23 00:00:00 EST 2004
A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research
Daneshmand M,Parolin DA,Hirte HW,Major P,Goss G,Stewart D,Batist G,Miller WH,Matthews S,Seymour L,Lorimer IA
MA5-12835 was used in immunohistochemistry to study the pharmacodynamics of an EGFR tyrosine kinase inhibitor in metastatic colorectal cancer patients
Tue Jul 01 00:00:00 EDT 2003
Improved endometrial assessment using cyclin E and p27.
Fertility and sterility
Dubowy RL,Feinberg RF,Keefe DL,Doncel GF,Williams SC,McSweet JC,Kliman HJ
MA5-12835 was used in immunohistochemistry to evaluate cyclin E and p27 as developmental markers for endometrium
Tue Jul 01 00:00:00 EDT 2003
Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Claudio PP,Zamparelli A,Garcia FU,Claudio L,Ammirati G,Farina A,Bovicelli A,Russo G,Giordano GG,McGinnis DE,Giordano A,Cardi G
MA5-12835 was used in immunohistochemistry to study the expression and prognostic value of cell-cycle-regulated proteins in prostatic gland adenocarcinoma
Sat Jun 01 00:00:00 EDT 2002
The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination.
Development (Cambridge, England)
Chen P,Johnson JE,Zoghbi HY,Segil N
MA5-12835 was used in immunohistochemistry to investigate the role of Math1 in the development of hair cells in inner ear
Wed May 01 00:00:00 EDT 2002
Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).
Journal of the National Cancer Institute
Lu Y,Zi X,Zhao Y,Mascarenhas D,Pollak M
MA5-12835 was used in western blot to study whether IGF-I interferes with the growth-inhibitory action of trastuzumab in breast cancer cells
Wed Dec 19 00:00:00 EST 2001
p27Kip1 localizes to detergent-insoluble microdomains within lymphocyte membranes.
Molecular medicine (Cambridge, Mass.)
Yaroslavskiy BB,Stolz DB,Watkins SC,Alber SM,Bradbury NA,Steinman RA
MA5-12835 was used in immunocytochemistry to study the presence and significance of p27Kip1 in detergent-insoluble microdomains within lymphocyte membranes
Mon Jan 01 00:00:00 EST 2001
p27Kip1 expression is associated with clinical outcome in advanced epithelial ovarian cancer: multivariate analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research
Masciullo V,Ferrandina G,Pucci B,Fanfani F,Lovergine S,Palazzo J,Zannoni G,Mancuso S,Scambia G,Giordano A
MA5-12835 was used in immunohistochemistry to investigate the prognostic significance of the p27(Kip1) in advanced epithelial ovarian cancer
Fri Dec 01 00:00:00 EST 2000
Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity.
Molecular and cellular biology
Tsutsui T,Hesabi B,Moons DS,Pandolfi PP,Hansel KS,Koff A,Kiyokawa H
MA5-12835 was used in western blot to study the role of CDK4 in cell cycle regulation using targeted knockdown
Fri Oct 01 00:00:00 EDT 1999
The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.
Genes & development
Reynisdóttir I,Massagué J
MA5-12835 was used in immunocytochemistry to study the role of p15(Ink4b) and p27(Kip1) subcellular localization in the coordinate regulation of cdk2 and cdk4
Sat Feb 15 00:00:00 EST 1997