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MA1-91593 detects Caspase 6 from human samples.
MA1-91593 has been successfully used in immunoprecipitation, immunohistochemistry (paraffin tissue), Western blot applications.
The MA1-91593 immunogen is: Recombinant caspase 6 prodomain (Human).
Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Apoptotic protease Mch-2; CASP-6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6; Caspase-6 subunit p10; Caspase-6 subunit p11; Caspase-6 subunit p18; Caspase-6 subunit p20; mCASP-6
Gene Aliases: CASP6; MCH2
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