Product References
Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy.
Scientific reports
Wang Y,Kang S,Khan A,Ruttner G,Leigh SY,Murray M,Abeytunge S,Peterson G,Rajadhyaksha M,Dintzis S,Javid S,Liu JT
MA5-12759 was used in flow cytometry to learn about intraoperative guidance of breast cancer lumpectomy by quantitative molecular phenotyping with topically applied SERS nanoparticles
Tue Feb 16 00:00:00 EST 2016
Multiplexed Molecular Imaging of Biomarker-Targeted SERS Nanoparticles on Fresh Tissue Specimens with Channel-Compressed Spectrometry.
PloS one
Kang S,Wang Y,Reder NP,Liu JT
MA512759 was used in immunohistochemistry to perform Raman-encoded molecular imaging with five nanoparticle flavors
Wed Nov 20 00:00:00 EST 2019
Isolation of breast cancer and gastric cancer circulating tumor cells by use of an anti HER2-based microfluidic device.
Lab on a chip
Galletti G,Sung MS,Vahdat LT,Shah MA,Santana SM,Altavilla G,Kirby BJ,Giannakakou P
MA5-12759 was used in flow cytometry, immunocytochemistry, and western blot to study the ability of a microfluidic device utilizing an anti-HER2 antibody to isolate circulating breast cancer and gastric cancer tumor cells
Tue Jan 07 00:00:00 EST 2014
Oxidatively modified proteins as plasma biomarkers in breast cancer.
Cancer biomarkers : section A of Disease markers
Jin H,Daly DS,Marks JR,Zangar RC
MA5-12759 was used in ELISA to study the value of posttranslationally modified secreted breast proteins in plasma as diagnostic markers of breast cancer
Mon May 12 00:00:00 EDT 2014
Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors.
Bioorganic & medicinal chemistry
Gunaherath GM,Marron MT,Wijeratne EM,Whitesell L,Gunatilaka AA
MA5-12759 was used in immunocytochemistry and western blot to develop potent Hsp90 inhibitors based on novobiocin analogues
Sun Sep 01 00:00:00 EDT 2013
Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers.
Pharmaceuticals (Basel, Switzerland)
Hernandez LI,Flenker KS,Hernandez FJ,Klingelhutz AJ,McNamara JO,Giangrande PH
MA5-12759 was used in immunocytochemistry to develop methods for the isolation and characterization of RNA aptamers that internalize following binding to their cognate receptors on the cell surface
Thu Mar 14 00:00:00 EDT 2013
Multiple breast cancer cell-lines derived from a single tumor differ in their molecular characteristics and tumorigenic potential.
PloS one
Mosoyan G,Nagi C,Marukian S,Teixeira A,Simonian A,Resnick-Silverman L,DiFeo A,Johnston D,Reynolds SR,Roses DF,Mosoian A
MA5-12759 was used in flow cytometry to study the different molecular phenotype and tumorigenicity of 5 breast cancer cell lines derived from a single patient
Fri Jul 26 00:00:00 EDT 2013
Multiplexed cancer biomarker detection using quartz-based photonic crystal surfaces.
Analytical chemistry
Huang CS,Chaudhery V,Pokhriyal A,George S,Polans J,Lu M,Tan R,Zangar RC,Cunningham BT
MA5-12759 was used in ELISA to develop a quartz-based photonic crystal surface for multiplexed cancer biomarker detection
Tue Jan 17 00:00:00 EST 2012
Development, characterization, and applications of a novel estrogen receptor beta monoclonal antibody.
Journal of cellular biochemistry
Wu X,Subramaniam M,Negron V,Cicek M,Reynolds C,Lingle WL,Goetz MP,Ingle JN,Spelsberg TC,Hawse JR
Published figure using ErbB2 (HER-2) monoclonal antibody (Product # MA5-12759) in Immunocytochemistry
Wed Feb 01 00:00:00 EST 2012
Circulating Tumor Cells Detected by RT-PCR for CK-20 before Surgery Indicate Worse Prognostic Impact in Triple-Negative and HER2 Subtype Breast Cancer.
Journal of breast cancer
Hwang SB,Bae JW,Lee HY,Kim HY
MA5-12759 was used in immunohistochemistry to study the prognostic value of circulating T cells expressing CK-20 mRNA in operable triple negative and HER2 subtypes of breast cancer
Thu Mar 01 00:00:00 EST 2012
T cell receptor-like recognition of tumor in vivo by synthetic antibody fragment.
PloS one
Miller KR,Koide A,Leung B,Fitzsimmons J,Yoder B,Yuan H,Jay M,Sidhu SS,Koide S,Collins EJ
MA5-12759 was used in Flow Cytometry to develop a synthetic antibody-fragment library in the phage-display format and isolate antibody-fragments that bind pMHC with high affinity and specificity.
Wed Jan 16 00:00:00 EST 2013
Enrichment of circulating tumor cells from a large blood volume using leukapheresis and elutriation: proof of concept.
Cytometry. Part B, Clinical cytometry
Eifler RL,Lind J,Falkenhagen D,Weber V,Fischer MB,Zeillinger R
MA5-12759 was used in immunocytochemistry to develop a process involving leukapheresis, elutriation and FACS to isolate circulating tumor cells from large volumes
Tue Mar 01 00:00:00 EST 2011
Phase II Study of Vinorelbine Plus Trastuzumab in HER2 Overexpressing Metastatic Breast Cancer Pretreated with Anthracyclines and Taxanes.
Journal of breast cancer
Lee YR,Huh SJ,Lee DH,Yoon HH,Seol YM,Choi YJ,Kwon KA,Lee S,Oh SY,Kim SH,Kim HJ,Kwon HC
MA5-12759 was used in immunohistochemistry to study the safety and efficacy of vinorelbine plus trastuzumab in a phase II clinical trial of HER2-overexpressing metastatic breast cancer patients pre-treated with anthracyclines and taxanes
Wed Jun 01 00:00:00 EDT 2011
Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma.
PloS one
Menju T,Hashimoto S,Hashimoto A,Otsuka Y,Handa H,Ogawa E,Toda Y,Wada H,Date H,Sabe H
MA5-12759 was used in immunohistochemistry to investigate the relationship between Her2 and GEP100 and their influence on lung cancer invasion
Fri Feb 10 00:00:00 EST 2012
Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status.
Clinical cancer research : an official journal of the American Association for Cancer Research
Kimple RJ,Vaseva AV,Cox AD,Baerman KM,Calvo BF,Tepper JE,Shields JM,Sartor CI
MA5-12759 was used in immunoprecipitation to study the role of EGFR/HER2 signaling in radiosensitization of pancreatic cancer
Mon Feb 01 00:00:00 EST 2010
Early response to ErbB2 over-expression in polarized Caco-2 cells involves partial segregation from ErbB3 by relocalization to the apical surface and initiation of survival signaling.
Journal of cellular biochemistry
Pfister AB,Wood RC,Salas PJ,Zea DL,Ramsauer VP
Published figure using ErbB2 (HER-2) monoclonal antibody (Product # MA5-12759) in Immunocytochemistry
Fri Oct 15 00:00:00 EDT 2010
Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity.
The Prostate
Mahajan K,Challa S,Coppola D,Lawrence H,Luo Y,Gevariya H,Zhu W,Chen YA,Lawrence NJ,Mahajan NP
MA5-12759 was used in immunoprecipitation to investigate the effect of Ackl tyrosine kinase inhibitor on androgen receptor activity and prostate cancer progression
Wed Sep 01 00:00:00 EDT 2010
Clinical outcomes and breast cancer subtypes in patients with brain metastases.
Onkologie
Kwon HC,Oh SY,Kim SH,Lee S,Kwon KA,Choi YJ,Cho GJ,Kim YS,Lee M,Lee JH,Kim DC,Lee HS,Cho SH,Kim HJ
MA5-12759 was used in immunohistochemistry to study clinical outcomes by breast cancer subtype in patients with brain metastases
Thu Jul 22 00:00:00 EDT 2010
Trastuzumab mediated T-cell response against HER-2/neu overexpressing esophageal adenocarcinoma depends on intact antigen processing machinery.
PloS one
Milano F,Guarriera M,Rygiel AM,Krishnadath KK
MA5-12759 was used in flow cytometry to investigate the mechanism of trastuzumab-induced immune response against esophageal adenocarcinoma
Thu Aug 26 00:00:00 EDT 2010
Molecular profile of ductal carcinoma in situ of the breast in BRCA1 and BRCA2 germline mutation carriers.
Journal of clinical pathology
van der Groep P,van Diest PJ,Menko FH,Bart J,de Vries EG,van der Wall E
MA5-12759 was used in immunohistochemistry to study the immunophenotype of ductal carcinoma in situ of the breast in subjects with germline mutations of BRCA1 and BRCA2
Thu Oct 01 00:00:00 EDT 2009
Trastuzumab activates allogeneic or autologous antibody-dependent cellular cytotoxicity against malignant rhabdoid tumor cells and interleukin-2 augments the cytotoxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research
Katsumi Y,Kuwahara Y,Tamura S,Kikuchi K,Otabe O,Tsuchiya K,Iehara T,Kuroda H,Hosoi H,Sugimoto T
MA5-12759 was used in immunocytochemistry to investigate the mechanism for the malignant rhabdoid tumor treatment with trastuzumab
Fri Feb 15 00:00:00 EST 2008
Expression pattern of immune suppressive cytokines and growth factors in oesophageal adenocarcinoma reveal a tumour immune escape-promoting microenvironment.
Scandinavian journal of immunology
Milano F,Jorritsma T,Rygiel AM,Bergman JJ,Sondermeijer C,Ten Brinke A,vanHam SM,Krishnadath KK
MA5-12759 was used in immunohistochemistry to study the expression of immunosuppressive cytokines and growth factors in oesophageal adenocarcinoma and the significance for immune escape
Mon Dec 01 00:00:00 EST 2008
Growth factor receptors expression in anaplastic thyroid carcinoma: potential markers for therapeutic stratification.
Human pathology
Elliott DD,Sherman SI,Busaidy NL,Williams MD,Santarpia L,Clayman GL,El-Naggar AK
MA5-12759 was used in immunohistochemistry to study the expression of growth factor receptors in anaplastic thyroid carcinoma and their potential utility for therapeutic stratification
Tue Jan 01 00:00:00 EST 2008
Caspase cleavage of HER-2 releases a Bad-like cell death effector.
The Journal of biological chemistry
Strohecker AM,Yehiely F,Chen F,Cryns VL
MA5-12759 was used in immunocytochemistry to study the release of a Bad-like cell death effector by caspase cleavage of HER-2
Fri Jun 27 00:00:00 EDT 2008
Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics.
Clinical cancer research : an official journal of the American Association for Cancer Research
Zhang JG,Eguchi J,Kruse CA,Gomez GG,Fakhrai H,Schroter S,Ma W,Hoa N,Minev B,Delgado C,Wepsic HT,Okada H,Jadus MR
MA5-12759 was used in flow cytometry to examine the allogenic glioma cells for the generation of therapeutic vaccines or cellular therapy
Mon Jan 15 00:00:00 EST 2007
Tumor-specific dendritic cells generated by genetic redirection of Toll-like receptor signaling against the tumor-associated antigen, erbB2.
Cancer gene therapy
Xu Y,Darcy PK,Kershaw MH
MA5-12759 was used in flow cytometry to generate tumor-specific dendritic cells for potential development of anti-tumor cell-based vaccines
Sat Sep 01 00:00:00 EDT 2007
Novel engineered trastuzumab conformational epitopes demonstrate in vitro and in vivo antitumor properties against HER-2/neu.
Journal of immunology (Baltimore, Md. : 1950)
Garrett JT,Rawale S,Allen SD,Phillips G,Forni G,Morris JC,Kaumaya PT
MA5-12759 was used in flow cytometry to evaluate the therapeutic potential of engeered trastuzumab conformational epitopes
Fri Jun 01 00:00:00 EDT 2007
A large-scale proteomic analysis of human embryonic stem cells.
BMC genomics
Schulz TC,Swistowska AM,Liu Y,Swistowski A,Palmarini G,Brimble SN,Sherrer E,Robins AJ,Rao MS,Zeng X
MA5-12759 was used in immunocytochemistry to study the proteome of human embryonic stem cells
Thu Dec 27 00:00:00 EST 2007
Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth.
Clinical cancer research : an official journal of the American Association for Cancer Research
Gregory CW,Whang YE,McCall W,Fei X,Liu Y,Ponguta LA,French FS,Wilson EM,Earp HS
MA5-12759 was used in immunoprecipitation to study the mechanism by which heregulin increases androgen receptor transactivation and proliferation in prostate cancer
Tue Mar 01 00:00:00 EST 2005
Inhibition of HER-2/neu kinase impairs androgen receptor recruitment to the androgen responsive enhancer.
Cancer research
Liu Y,Majumder S,McCall W,Sartor CI,Mohler JL,Gregory CW,Earp HS,Whang YE
MA5-12759 was used in immunoprecipitation to investigate the role of Her-2/neu kinase in the androgen receptor signalling transduction pathway
Fri Apr 15 00:00:00 EDT 2005
Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors.
Breast cancer research and treatment
Chan CT,Metz MZ,Kane SE
MA5-12759 was used in flow cytometry to investigate the mechanism for the trastuzumab resistence in human breast cancer treatment
Sun May 01 00:00:00 EDT 2005
Conformational HER-2/neu B-cell epitope peptide vaccine designed to incorporate two native disulfide bonds enhances tumor cell binding and antitumor activities.
The Journal of biological chemistry
Dakappagari NK,Lute KD,Rawale S,Steele JT,Allen SD,Phillips G,Reilly RT,Kaumaya PT
MA5-12759 was used in flow cytometry to develop a conformational HER-2/neu B-cell epitope peptide vaccine thast enhances tumor cell binding and antitumor activities
Fri Jan 07 00:00:00 EST 2005
Docetaxel combined with trastuzumab is an active regimen in HER-2 3+ overexpressing and fluorescent in situ hybridization-positive metastatic breast cancer: a multi-institutional phase II trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Tedesco KL,Thor AD,Johnson DH,Shyr Y,Blum KA,Goldstein LJ,Gradishar WJ,Nicholson BP,Merkel DE,Murrey D,Edgerton S,Sledge GW
MA5-12759 was used in immunohistochemistry to study the efficacy and safety of docetaxel and trastuzumab in HER-2-overexpressing metastatic breast cancer
Mon Mar 15 00:00:00 EST 2004
AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity.
Cancer research
Traxler P,Allegrini PR,Brandt R,Brueggen J,Cozens R,Fabbro D,Grosios K,Lane HA,McSheehy P,Mestan J,Meyer T,Tang C,Wartmann M,Wood J,Caravatti G
MA5-12759 was used in ELISA to suggest that AEE788 is an anticancer agent that deregulates tumor cell proliferation and angiogenic parameters
Thu Jul 15 00:00:00 EDT 2004
Changes in the expression and cytological localization of betacellulin and its receptors (ErbB-1 and ErbB-4) in the trophoblasts in human placenta over the course of pregnancy.
European journal of endocrinology
Tanimura K,Nakago S,Murakoshi H,Takekida S,Moriyama T,Matsuo H,Hashimoto K,Maruo T
MA5-12759 was used in immunohistochemistry to study the expression of betacellulin and its receptors in trophoblasts in human placenta over the course of pregnancy
Thu Jul 01 00:00:00 EDT 2004
HER-2/neu overexpression increases the viable hypoxic cell population within solid tumors without causing changes in tumor vascularization.
Molecular cancer research : MCR
Dragowska WH,Warburton C,Yapp DT,Minchinton AI,Hu Y,Waterhouse DN,Gelmon K,Skov K,Woo J,Masin D,Huxham LA,Kyle AH,Bally MB
MA5-12759 was used in flow cytometry to study the role of HER-2/neu overexpression in increasing the viable hypoxic cell population within solid tumors
Mon Nov 01 00:00:00 EST 2004
Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer.
Journal of immunology (Baltimore, Md. : 1950)
Kershaw MH,Jackson JT,Haynes NM,Teng MW,Moeller M,Hayakawa Y,Street SE,Cameron R,Tanner JE,Trapani JA,Smyth MJ,Darcy PK
MA5-12759 was used in flow cytometry to study the use of gene-engineered T cells as a superior adjuvant therapy for metastatic cancer.
Sun Aug 01 00:00:00 EDT 2004
Transmembrane peptides as inhibitors of ErbB receptor signaling.
Molecular biology of the cell
Bennasroune A,Fickova M,Gardin A,Dirrig-Grosch S,Aunis D,Crémel G,Hubert P
MA5-12759 was used in immunocytochemistry to investigate the interaction between transmembrane domain of receptor tyrosine kinases and ErbB receptor
Thu Jul 01 00:00:00 EDT 2004
Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK.
Molecular biology of the cell
Kansra S,Stoll SW,Johnson JL,Elder JT
MA5-12759 was used in immunoprecipitation to investigate the mechanism of ERK autocrine activation in normal human keratinocytes
Wed Sep 01 00:00:00 EDT 2004
Cytotoxicity of the novel anti-cancer drug rViscumin depends on HER-2 levels in SKOV-3 cells.
Biochemical and biophysical research communications
Abuharbeid S,Apel J,Sander M,Fiedler B,Langer M,Zuzarte ML,Czubayko F,Aigner A
MA5-12759 was used in flow cytometry to study the relationship between cytotoxicity of the anti-cancer drug rViscumin and HER-2 levels in SKOV-3 cells
Fri Aug 20 00:00:00 EDT 2004
Effects of cytochalasin D on the actin cytoskeleton: association of neoformed actin aggregates with proteins involved in signaling and endocytosis.
Cellular and molecular life sciences : CMLS
Mortensen K,Larsson LI
MA5-12759 was used in immunocytochemistry to study the interaction of cytochalasin D with the actin cytoskeleton
Thu May 01 00:00:00 EDT 2003
A chimeric multi-human epidermal growth factor receptor-2 B cell epitope peptide vaccine mediates superior antitumor responses.
Journal of immunology (Baltimore, Md. : 1950)
Dakappagari NK,Pyles J,Parihar R,Carson WE,Young DC,Kaumaya PT
MA5-12759 was used in flow cytometry and immunoprecipitation to develop and evaluate a multi-epitope vaccine targeting HER-2
Tue Apr 15 00:00:00 EDT 2003
Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells.
The Journal of biological chemistry
Ramsauer VP,Carraway CA,Salas PJ,Carraway KL
MA5-12759 was used in immunocytochemistry to investigate the translocation of ErbB2 to the apical surface in polarized epithelial cells
Fri Aug 08 00:00:00 EDT 2003
Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors.
Blood
Haynes NM,Trapani JA,Teng MW,Jackson JT,Cerruti L,Jane SM,Kershaw MH,Smyth MJ,Darcy PK
MA5-12759 was used in flow cytometry to study enginered single-chain antigen recognition receptors that co-stimulate potent rejection of established experimental tumors
Fri Nov 01 00:00:00 EST 2002
Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition.
Clinical cancer research : an official journal of the American Association for Cancer Research
MacKeigan JP,Taxman DJ,Hunter D,Earp HS,Graves LM,Ting JP
MA5-12759 was used in immunoprecipitation to study the inactivation of the antiapoptotic PI3 kinase-Akt pathway by a combination of taxol and MAP kinase kinase inhibition
Mon Jul 01 00:00:00 EDT 2002
Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain.
Cancer research
Kashentseva EA,Seki T,Curiel DT,Dmitriev IP
MA5-12759 was used in immunocytochemistry to develop an adenovirus targeting the c-erbB2 oncoprotein for cancer therapy
Tue Jan 15 00:00:00 EST 2002
Basolateral targeting of ERBB2 is dependent on a novel bipartite juxtamembrane sorting signal but independent of the C-terminal ERBIN-binding domain.
Molecular and cellular biology
Dillon C,Creer A,Kerr K,Kümin A,Dickson C
MA5-12759 was used in immunocytochemistry to study the role of a novel bipartite juxtamembrane sorting signal in the basolateral targeting of ERBB2
Sun Sep 01 00:00:00 EDT 2002
Anti-HER2 antibody enhances the growth inhibitory effect of anti-oestrogen on breast cancer cells expressing both oestrogen receptors and HER2.
British journal of cancer
Kunisue H,Kurebayashi J,Otsuki T,Tang CK,Kurosumi M,Yamamoto S,Tanaka K,Doihara H,Shimizu N,Sonoo H
MA5-12759 was used in flow cytometry to investigate the synergistic inhibitory effect of anti-HER2 antibody and anti-oestrogen on breast cancer cells
Sat Jan 01 00:00:00 EST 2000
Reversal of HER-2 over-expression renders human ovarian cancer cells highly resistant to taxol.
Toxicology
Aigner A,Hsieh SS,Malerczyk C,Czubayko F
MA5-12759 was used in flow cytometry to study the role of the HER-2 receptor in modulating the response of ovarian cancer cells to doxorubicin, cisplatin and taxol
Mon Apr 03 00:00:00 EDT 2000
Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo.
Cancer research
Tang CK,Concepcion XZ,Milan M,Gong X,Montgomery E,Lippman ME
MA5-12759 was used in flow cytometry to study the role of ErbB-4 in the proliferation of estrogen receptor-positive breast cancer cells
Fri Oct 15 00:00:00 EDT 1999
ErbB-4 ribozymes abolish neuregulin-induced mitogenesis.
Cancer research
Tang CK,Goldstein DJ,Payne J,Czubayko F,Alimandi M,Wang LM,Pierce JH,Lippman ME
MA5-12759 was used in immunocytochemistry to investigate the effect of ErbB-4 ribozymes on neuregulin-induced mitogenesis
Sat Aug 01 00:00:00 EDT 1998