Genomics and proteomics search results

BRAF [V599E] Recombinant Human Protein

BRAF acts upstream of MEK in the MAP kinase pathway and is involved in cell division, differentiation, and secretion. The BRAF mutant V599E is oncogenic and found in a variety of cancers. ...

Specifications

Gene ID
10488, 673
Species
Human
Target Gene
v-raf murine sarcoma viral oncogene homolog B1
Gene Aliases
BRAF V599E
Kinase Group
Ser⁄Thr Kinases: TKL Group
Protein Family
Kinases & Inhibitors
Protein Subtype
Serine⁄Threonine Kinases
Accession Number
NP_004324.1, V599E
Molecular Weight
67.1 kDa
Research Category
Oncology
Signal Transduction
System Compatibility
Z'-LYTE™
LanthaScreen® Antibody
LanthaScreen® Substrate
Validated Application
Kinase Assay
Protein Length or Portion (a.a.)
aa 416-766
Protein Tag or Fusion
GST Tag
Tag Position
N-Terminal
Expression
Baculovirus
Kinase Family
RAF Kinase Family
Protein Form
Catalytic
Recombinant
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV3849
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BRAF Recombinant Human Protein

BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play a role in the postsynaptic responses of hippocampal neuron. ...

Specifications

Gene ID
2353, 673
Species
Human
Target Gene
v-raf murine sarcoma viral oncogene homolog B1
Gene Aliases
BRAF, BRAF1
Kinase Group
Ser⁄Thr Kinases: TKL Group
Protein Family
Kinases & Inhibitors
Protein Subtype
Serine⁄Threonine Kinases
Accession Number
NP_004324.2
Molecular Weight
113.6 kDa
Research Category
Oncology
Signal Transduction
System Compatibility
Z'-LYTE™
LanthaScreen® Substrate
LanthaScreen® Antibody
Omnia® Bulk Substrate
Validated Application
Kinase Assay
Protein Tag or Fusion
GST Tag
Expression
Baculovirus
Kinase Family
RAF Kinase Family
Protein Form
Full Length
Recombinant
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV3848
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Yotiao Rabbit Polyclonal Antibody

Rabbit anti-Yotiao; Unconjugated Polyclonal antibody specific to Human, Mouse, Rat Yotiao. This antibody is validated for use in Western Blot, Immunoassay (ELISA). Anti-Yotiao recognizes the expressed product of the AKAP9 gene. ...

Specifications

Reactivity
Mouse
Human
Rat
Validated Application
Immunoprecipitation
Western Blot
ELISA
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
Yotiao
Gene ID
10142
Label or Dye
Unconjugated
Purification
Epitope Affinity Purified
Shipping Condition
Wet Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

360300
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LanthaScreen® Tb-pMAP2K1 (pSer217⁄221) Antibody

A member of the MAP Kinase family, MAP2K1 (mitogen-activated protein kinase kinase 1) is phosphorylated at Ser217⁄221 by a range of MAPK family members including Raf and B-Raf.
For use in combination with the Fluorescein-MAP2K1 physiological protein substrate (PV4812) to evalu ...

Specifications

Readout
End Point
Reactivity
Human
Target Gene
Ser/Thr Kinases
Label or Dye
Tb (Terbium)
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV4818
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TaqMan® Mutation Detection Assays

TaqMan® Mutation Detection Assays detect somatic mutations in genes that are associated with cancer. These assays are powered by competitive allele-specific TaqMan® PCR (castPCR™) technology. Specific and sensitive, castPCR™ can detect rare mutated DNA among wild-type DNA. ...

Specifications

Search Display
config
Shipping Condition
Room Temperature

Related Applications

4465804
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LanthaScreen® ERK2 A375 Cell Line

The Map Kinase (MapK) signal transduction cascade is activated by growth factors such as EGF, PDGF, and HGF. Binding of these factors to their respective cell surface receptors results in the initiation of receptor tyrosine kinase activity, which leads to the sequential phospho- ...

Specifications

System
LanthaScreen®
Readout
End Point
Cell Line
A375
Technique
TR-FRET
Cell State
Dividing Cells
Antagonists
Raf Inhibitor I
Gene Symbol
ERK2
Primary Agonist
Constitutive
Detection Method
Fluorescent
Druggable Target
Signaling Pathway
Kinases
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

K1798
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TaqMan® EGFR Exon 19 Deletions Assay

TaqMan® Mutation Detection Assays detect somatic mutations in genes that are associated with cancer. These assays are powered by competitive allele-specific TaqMan® PCR (castPCR™) technology. Specific and sensitive, castPCR™ can detect rare mutated DNA among wild-type DNA. ...

Specifications

Search Display
config
Shipping Condition
Room Temperature

Related Applications

4465805
54e0a8b4ca215f4f195ada1a350a11cd_CmgtBuyProduct

TaqMan® Mutation Detection Reference Assays

TaqMan® Mutation Detection Assays detect somatic mutations in genes that are associated with cancer. These assays are powered by competitive allele-specific TaqMan® PCR (castPCR™) technology. Specific and sensitive, castPCR™ can detect rare mutated DNA among wild-type DNA. ...

Specifications

Search Display
config
Shipping Condition
Room Temperature

Related Applications

4465807
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CellSensor® AP-1-bla A375 Cell Line

The CellSensor® AP1-bla A375 cell line contains a beta-lactamase reporter gene under control of the AP1 response element stably integrated into A375 cells. A375 cells are human melanoma cancer cells that contain the endogenous B-Raf mutation V600E resulting in constitutive B-Raf ...

Specifications

System
CellSensor™
Cell State
Dividing Cells
Druggable Target
Signaling Pathway
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

K1660
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Ion AmpliSeq™ RNA Cancer Panel

The Ion AmpliSeq™ RNA Cancer Panel is a screening tool designed against 50 oncogenes/tumor suppressor genes found in the COSMIC database. This panel has been developed as an RNA complement to the DNA-focused Ion AmpliSeq™ Cancer Hotspot Panel v2. The panel is a single pool of ...

Specifications

Platform
Ion PGM™ System
Library Type
Targeted Sequencing Library
Workflow Step
Target Selection
Starting Material
Total RNA
Sequencing Type
Transcriptome Sequencing
Species
Human
Technique
Amplicon Sequencing
Sample Type (Specific)
RNA (>500 bases)
Tissue (FFPE)
Starting Material (Amount)
500 pg of total RNA from fresh frozen tissue or 5 ng of RNA from FFPE samples
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

4482572
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TaqMan® Genotyping Master Mix

The Applied Biosystems® TaqMan® Genotyping Master Mix is optimized for end-point fluorescence detection in SNP genotyping applications. ...

Specifications

Platform
StepOnePlus™, Standard Mode
7900HT System
StepOne™, Standard Mode
7500 System
7000 System
7300 System
Technique
SNP Genotyping (Real-Time PCR-Based)
CNV (Copy Number Variation)
PCR Method
qPCR
Polymerase
AmpliTaq Gold® DNA Polymerase
Reaction Speed
Standard
Detection Method
Primer-Probe Detection
Genotyping Target
SNPs (Unknown or Numerous)
Drug Metabolizing Enzymes
SNPs (Known)
Copy Number Variants
Passive Reference Dye
ROX (Pre-mixed)
Sample Type (General)
DNA
Sample Type (Specific)
DNA (Genomic)
Purity or Quality Grade
UP (Ultra Pure)
Primer-Probe Compatibility
TaqMan®
Shipping Condition
Wet Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

4371355
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