mTOR/FRAP [pS2448] Oligoclonal Antibody (clone 8HCLC), ABfinity™ Recombinant

This purified oligoclonal recombinant rabbit IgG antibody recognizes human Mammalian Target of Rapamycin (mTOR) [pS2448]. ...

Specifications

Reactivity
Human
Validated Application
ELISA
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Clone ID
8HCLC
Antibody Fragment
Whole Antibody
Gene ID
2475
Gene Symbol
TOR
Accession Number
P42345
Label or Dye
Unconjugated
Target Modification State
Phospho
Purification
Purified
Concentration
0.5 mg⁄ml
Form
Liquid
Neutralizing Antibody
No
Protein Family
Kinases & Inhibitors
Comments
Oligoclonal (Pool of Monoclonal Abs to Several Epitopes)
Research Category
Signal Transduction
Shipping Condition
Wet Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

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mTOR/FRAP [pS2448] Rabbit Polyclonal Antibody

MTOR [pS2448] PAb; Unconjugated Polyclonal antibody specific to Human, Mouse, H, (Rat) mTOR [pS2448]. This antibody is validated for use in Western Blot, Immunocytochemistry⁄ Immunofluorescence. Anti-mTOR [pS2448] recognizes the expressed product of the FRAP1 gene. Catalog numbe ...

Specifications

Reactivity
Mouse
Human
Validated Application
Immunofluorescence
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
mTOR/FRAP [pS2448]
Gene ID
2475
Label or Dye
Unconjugated
Target Modification State
Phospho
Purification
Purified
Protein Family
Kinases & Inhibitors
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

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mTOR Monoclonal Antibody (clone 7H13L18), ABfinity™ Recombinant

This is a purified rabbit anti-human mTOR monoclonal antibody that can be use in the validated applications of indirect ELISA, Western blot, and immunocytochemistry. ...

Specifications

Reactivity
Human
Validated Application
Flow Cytometry
Immunocytochemistry
Western Blot
ELISA
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Monoclonal
Clone ID
7H13L18
Antibody Fragment
Whole Antibody
Target Gene
mechanistic target of rapamycin (serine/threonine kinase)
Gene ID
2475
Gene Symbol
MTOR
Accession Number
P42345
Gene Aliases
FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Label or Dye
Unconjugated
Concentration
0.5 mg⁄ml
Form
Liquid
Protein Family
Kinases & Inhibitors
Buffer
PBS (Phosphate Buffered Saline)
Research Category
Signal Transduction
Other Additives
Sodium Azide Preservative
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

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701483
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FRAP1 (mTOR) Recombinant Human Protein

FRAP1 (mTOR) is a serine⁄threonine kinase that plays a critical role in cellular growth and proliferation. Perturbations in the mTOR⁄PI3-kinase⁄AKT pathway are associated with numerous forms of cancer. FRAP1 is also the target of rapamycin and its analogues, which are currently ...

Specifications

Species
Human
Target Gene
FK506 binding protein 12-rapamycin associated protein 1
Gene Aliases
FRAP1 (mTOR)
Kinase Group
Ser⁄Thr Kinases: Atypical
Protein Family
Kinases & Inhibitors
Protein Subtype
Serine⁄Threonine Kinases
Accession Number
NP_004949.1
Molecular Weight
163.9 kDa
Research Category
Oncology
Signal Transduction
System Compatibility
Z'-LYTE™
LanthaScreen® Antibody
LanthaScreen® Substrate
Validated Application
Kinase Assay
Protein Length or Portion (a.a.)
aa 1360-2549
Protein Tag or Fusion
GST Tag
Expression
Baculovirus
Kinase Family
PIKK Kinase Family
Protein Form
Catalytic
Recombinant
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

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mTOR Oligoclonal Antibody, ABfinity™ Recombinant

This is a purified rabbit anti-human mTOR antibody that can be used in validated applications such as indirect ELISA, western blot (WB), flow cytometry (FC), and immunocytochemistry (ICC). ...

Specifications

Reactivity
Human
Validated Application
Flow Cytometry
Immunocytochemistry
Western Blot
ELISA
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Oligoclonal
Clone ID
7HCLC
Antibody Fragment
Whole Antibody
Target Gene
mechanistic target of rapamycin (serine/threonine kinase)
Gene ID
2475
Gene Symbol
MTOR
Accession Number
P42345
Gene Aliases
FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Label or Dye
Unconjugated
Concentration
0.5 mg⁄ml
Form
Liquid
Protein Family
Kinases & Inhibitors
Buffer
PBS (Phosphate Buffered Saline)
Research Category
Cell Cycle & Proliferation
Other Additives
Sodium Azide Preservative
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

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LanthaScreen® Tb-p4E-BP1 (pThr46) Antibody Kit

A part of the PI3K/AKT Pathway, 4E-BP1 (EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1) is a cytosolic protein that is phosphorylated at Thr46 by mTORC1 upon stimulation of the pathway. ...

Specifications

Format
384-well plate
Readout
End Point
Technique
TR-FRET
Reactivity
Human
Label or Dye
GFP (EmGFP)
Tb (Terbium)
Target Enzyme
Serine⁄Threonine Kinases
Validated Kinases
FRAP1 (mTOR)
FRAP1 (mTOR)
Antibody Molecular Weight
150000 Da
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

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mTOR Mouse Monoclonal Antibody (clone 215Q18)

mTOR MAb (215Q18) hu, ms, rt ; Unconjugated Monoclonal antibody specific to Human, Mouse, Rat mTOR. This antibody is validated for use in Western Blot. Anti-mTOR recognizes the expressed product of the FRAP1 gene. ...

Specifications

Reactivity
Rat
Mouse
Human
Validated Application
Western Blot
Host
Mouse
Clonality
Monoclonal
Clone ID
215Q18
Target Gene
mTOR
Gene ID
2475, 56717, 56718
Label or Dye
Unconjugated
Purification
Affinity Purified
Protein Family
Kinases & Inhibitors
Research Category
Signal Transduction
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

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LanthaScreen® Akt HEK 293E Cell Line

LanthaScreen® GFP Cellular Assays allow for the analysis of post-translational modifications for a number of target proteins in an live-cell context. The PI3K⁄AKT pathway mediates signals for cell growth, cell survival, transcription, translation, and glucose uptake. Because of t ...

Specifications

System
LanthaScreen®
Readout
TR-FRET
Reporter
GFP (EmGFP)
Cell Line
293E (HEK)
Cell State
Dividing Cells
Antagonists
LY294002
PI-103
Gene Symbol
AKT1
Primary Agonist
IGF-1
Detection Method
Fluorescent
Druggable Target
Signaling Pathway
Kinases
Optimal Response
IGF-1 (EC50 = 0.42 µg/ml)
Alternate Agonists
Insulin
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

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GFP-4E-BP1

4E-BP1 expressed as a fusion with GFP (Green Fluorescent Protein) to act as a physiological substrate for FRAP1 (mTor). ...

Specifications

Substrate
4E-BP1
Label or Dye
GFP (EmGFP)
Target Enzyme
Serine⁄Threonine Kinases
Substrate Type
Kinase Substrate
Detection Method
Fluorescent
Molecular Weight
45600 Da
Validated Kinases
FRAP1 (mTOR)
FRAP1 (mTOR)
Substrate Properties
Protein-Based Substrate
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

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Rapamycin

Rapamycin is a member of a family of macrolide immunosuppressants that bind to and inhibit the FK506 binding protein (FKBP) proline rotamase. ...

Specifications

Form
Solid
Gene ID
2475
Gene Symbol
MTOR
Gene Aliases
FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Molecular Weight
914.2 Da
Shipping Condition
Wet Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

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ACPP Recombinant Mouse Protein, His tag

Acid Phosphatase, prostate (ACPP), recombinant mouse protein is supplied as a lyophilized powder. In general, recombinant proteins can be used as protein stucture analysis and in cell biology research applications. ...

Specifications

Form
Lyophilized
Purity
≥ 90% by SDS-PAGE
Gene ID
56318
Species
Mouse
Expression
Mammalian
Gene Symbol
ACPP
Gene Aliases
9.104100899-104272570.1, 5'-NT, A030005E02Rik, FRAP, Lap, PAP, Ppal
Protein Form
Recombinant
Full Length
Purification
PAGE
Tag Position
C-Terminal
Protein Family
Other Proteins
Endotoxin Level
< 1 EU/µg
Molecular Weight
42 kDa
Protein Tag or Fusion
His Tag
Validated Application
Assay Standard
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

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