RAF1 (cRAF) [Y340D] [Y341D] Recombinant Human Protein

See all Serine⁄Threonine Kinases

Catalog # Unit Size List Price
PR7307A 100 µg 1250.00

Description

RAF1 (cRAF) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated RAF1 can   View full product details >

General Specifications

Form
Frozen
Species
Human
Gene Aliases
RAF1 (cRAF) Y340D Y341D
Kinase Group
Ser⁄Thr Kinases: TKL Group
Product Size
100 µg
Accession Number
NP_002871, Y340D, Y341D
Molecular Weight
66.4 kDa
Research Category
Drug Development
Validated Application
Kinase Assay
Protein Tag or Fusion
GST Tag
Expression
Baculovirus
Kinase Family
RAF Kinase Family
Protein Form
Catalytic
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Proteins, Expression, Isolation & Analysis
c5967704669e98ab233762c09bcc04af_CmgtBuyProduct

RAF1 Kinase Inhibitor I

Catalog # Unit Size List Price Contact us
PHZ1263 1 mg ***

Description

Raf1 Kinase Inhibitor I is a potent inhibitor of c-Raf1. This compound has been assessed with a number of other enzymes, including Cdk1, Cdk2, c-Src, ERK2, MEK, p38 MAPK,   View full product details >

General Specifications

Form
Solid
Sterility
Non-sterile
Product Size
1 mg
Purification
HPLC
Inhibitor Type
Kinase Inhibitor
Kinase Inhibitor (MAP Kinase Inhibitor)
Molecular Weight
520.9 Da
Inhibitor Properties
Chemical
Specific Inhibitor Target
c-RAF 1
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Cell Culture
  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
PHZ1263
928b8d65eefb4c6655767c6a14dc4bbe_CmgtBuyProduct

LanthaScreen® Tb-pMAP2K1 (pSer217⁄221) Antibody Kit

See all TR-FRET Primary Antibodies

Catalog # Unit Size List Price
PV4813 25 µg 3055.00

Description

A member of the MAP Kinase family, MAP2K1 (mitogen-activated protein kinase kinase 1) is phosphorylated at Ser217/221 by a range of MAPK family members including Raf and B-Raf. For   View full product details >

General Specifications

Format
384-well plate
Gene ID
10454, 10746, 1326, 4215, 4217, 4293, 4294, 4296, 5894, 673, 6885
Readout
End Point
Technique
TR-FRET
Reactivity
Human
Label or Dye
FITC (Fluorescein)
Tb (Terbium)
Product Size
25 µg
Target Enzyme
Serine⁄Threonine Kinases
Validated Kinases
BRAF, MAP3K2, MAP3K3, MAP3K5, MAP3K7, MAP3K8, MAP3K9, MAP3K10, MAP3K11
Antibody Molecular Weight
150000 Da
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
PV4813
e855eb49c706e7e710d29bba4250c25f_CmgtBuyProduct

Fluorescein-MAP2K1

See all Kinase & Phosphatase Substrates

Catalog # Unit Size List Price
PV4812 20 nmols 672.00

Description

Inactive MAP2K1 (MEK1) has been labeled with fluorescein, and is a substrate for MAPK family members.

For use in combination with the LanthaSreen™ Tb-MAP2K1   View full product details >

General Specifications

Gene ID
10454, 10746, 1326, 4215, 4217, 4293, 4294, 4296, 5894, 673, 6885
Substrate
MAP2K1
Label or Dye
FITC (Fluorescein)
Product Size
20 nmols
Target Enzyme
Serine⁄Threonine Kinases
Substrate Type
Kinase Substrate
Detection Method
Fluorescent
Molecular Weight
50000 Da
Validated Kinases
BRAF, MAP3K2, MAP3K3, MAP3K5, MAP3K7, MAP3K8, MAP3K9, MAP3K10, MAP3K11
Substrate Properties
Protein-Based Substrate
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
PV4812
18eee9eb639a078761b0f1e12691a0b9_CmgtBuyProduct

B-Raf Mouse mAb (clone 1C1G6A4)

See all Protein Specific Primary Antibodies

Catalog # Unit Size List Price
375600 100 µg 299.00

Description

Mouse anti-B-Raf; Unconjugated Monoclonal antibody specific to Human, Mouse B-Raf. This antibody is validated for use in Western Blot, Immunoassay (ELISA). Anti-B-Raf recognizes   View full product details >

General Specifications

Reactivity
Human
Mouse
Validated Application
Western Blot
ELISA
Host
Mouse
Clonality
Monoclonal
Clone ID
1C1G6A4
Target Gene
B-Raf
Gene ID
673
Label or Dye
Unconjugated
Purification
Affinity Purified
Product Size
100 µg
Shipping Condition
Wet Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Cell Analysis
  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
375600
f974ec825a45a63eae00718e0804c2de_CmgtBuyProduct

c-RAF Rabbit Polyclonal Antibody, Unconjugated

See all Protein Specific Primary Antibodies

Catalog # Unit Size List Price
44520G 100 µL 299.00

Description

c-RAF PAb hu, ms, (rt) ; Unconjugated Polyclonal antibody specific to Multiple c-Raf. This antibody is validated for use in Western Blot. Anti-c-Raf recognizes the expressed   View full product details >

General Specifications

Reactivity
Human
Mouse
Validated Application
Western Blot
Host
Rabbit
Clonality
Polyclonal
Target Gene
c-Raf
Gene ID
110157, 24703, 5894
Label or Dye
Unconjugated
Purification
Pure
Product Size
100 µL
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
44520G
3971e81c2096ec7d8a44dae762ecd408_CmgtBuyProduct

c-Raf [pSpY338/340] Rabbit Polyclonal Antibody

See all Protein Specific Primary Antibodies

Catalog # Unit Size List Price
44505G 10 blots 299.00

Description

c-RAF [pSpY338⁄340] PAb; Unconjugated Polyclonal antibody specific to Human, (Mouse, Rat) c-Raf [pS338⁄pY340]. This antibody is validated for use in Western Blot.   View full product details >

General Specifications

Reactivity
Human
Validated Application
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
c-Raf [pSpY338/340]
Gene ID
5894
Label or Dye
Unconjugated
Target Modification State
Phospho
Product Size
10 blots
Purity or Quality Grade
Azide Free
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Cell Analysis
  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
44505G
3c073df5b53394abf9911e102e843f7a_CmgtBuyProduct

Raf-1 Rabbit Polyclonal Antibody

See all Protein Specific Primary Antibodies

Catalog # Unit Size List Price
712600 100 µg 270.00

Description

Rabbit anti-Raf-1; Unconjugated Polyclonal antibody specific to Human, Mouse, Rat Raf-1 . This antibody is validated for use in Western Blot, Immunoassay (ELISA). Anti-Raf-1   View full product details >

General Specifications

Reactivity
Mouse
Rat
Human
Validated Application
Immunoprecipitation
ELISA
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
Raf-1
Gene ID
110157, 24703, 5894
Label or Dye
Unconjugated
Purification
Epitope Affinity Purified
Product Size
100 µg
Shipping Condition
Wet Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Cell Analysis
  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
712600
859fa608ec949927611de71118630eea_CmgtBuyProduct

CellSensor® AP-1-bla A375 Cell Line

See all Pathway Analysis Cell Based Assay Kits

Catalog # Unit Size List Price
K1660 1 vial 9880.00

Description

The CellSensor® AP1-bla A375 cell line contains a beta-lactamase reporter gene under control of the AP1 response element stably integrated into A375 cells. A375 cells are human   View full product details >

General Specifications

System
CellSensor™
Cell State
Dividing Cells
Product Size
1 vial
Druggable Target
Signaling Pathway
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Drug Discovery & Development
K1660
c2baabcd66bea9d777484bd2f7cfa81b_CmgtBuyProduct

BRAF Recombinant Human Protein

See all Serine⁄Threonine Kinases

Catalog # Unit Size List Price
PR6995A 100 µg 1250.00

Description

BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play   View full product details >

General Specifications

Form
Frozen
Species
Human
Gene Aliases
BRAF, BRAF1
Kinase Group
Ser⁄Thr Kinases: TKL Group
Product Size
100 µg
Accession Number
NP_004324.2
Molecular Weight
113.6 kDa
Research Category
Drug Development
Validated Application
Kinase Assay
Protein Tag or Fusion
GST Tag
Expression
Baculovirus
Kinase Family
RAF Kinase Family
Protein Form
Full Length
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Proteins, Expression, Isolation & Analysis
0a2b1278edf999dbb8e36344114b3323_CmgtBuyProduct

BRAF [V599E] Recombinant Human Protein

See all Serine⁄Threonine Kinases

Catalog # Unit Size List Price
PV3849 10 µg 379.00

Description

BRAF acts upstream of MEK in the MAP kinase pathway and is involved in cell division, differentiation, and secretion. The BRAF mutant V599E is oncogenic and found in a variety of   View full product details >

General Specifications

Mass
10 µg
Gene ID
10488, 673
Species
Human
Target Gene
v-raf murine sarcoma viral oncogene homolog B1
Gene Aliases
BRAF V599E
Kinase Group
Ser⁄Thr Kinases: TKL Group
Product Size
10 µg
Protein Family
Kinases & Inhibitors
Protein Subtype
Serine⁄Threonine Kinases
Accession Number
NP_004324.1, V599E
Molecular Weight
67.1 kDa
Research Category
Oncology
Signal Transduction
System Compatibility
LanthaScreen® Substrate
LanthaScreen® Antibody
Z'-LYTE™
Validated Application
Kinase Assay
Protein Length or Portion (a.a.)
aa 416-766
Protein Tag or Fusion
GST Tag
Tag Position
N-Terminal
Expression
Baculovirus
Kinase Family
RAF Kinase Family
Protein Form
Catalytic
Recombinant
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
PV3849
f3da3b4a37441c6edec685b12b155fdd_CmgtBuyProduct

Z′-LYTE® Kinase Assay Kit - Ser/Thr 3 Peptide

See all Kinase Assay Kits

Catalog # Unit Size List Price
PV3176 800 x 20 µL assays 530.00

Description

A coumarin and fluorescein-labeled peptide substrate which can be used for kinase screening in an antibody-free format. This peptide is based upon bovine MBP Thr-97 derived   View full product details >

General Specifications

Format
384-well plate
Readout
End Point
Technique
FRET
Assay Type
Serine⁄Threonine Kinase Assay
References
BBRC vol. 61, pp 559-563 (1974), JBC, vol 252, p 4888 (1978)
Label or Dye
Coumarin
Product Size
800 x 20 µL assays
Target Enzyme
Serine⁄Threonine Kinases
Validated Kinases
BRAF, MAPK1, MAPK3, MAPK12, MAPK13, MAP2K1, MAP2K2, MAP3K6, MAP2K8
Number of Reactions
800 Reactions
Substrate Properties
Peptide-Based Substrate
Protein or Peptide Source
Consensus seq Pro-X-(Ser⁄Thr)-Pro (APRTPGGRR)
Bovine MBP, Thr-97 derived peptide S5
Excitation⁄Emission (nm)
405⁄465, 535
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
PV3176
80cb8917b9a3c1ff43875579b27ff363_CmgtBuyProduct

c-Raf [pYpY340/341] Rabbit Polyclonal Antibody View 2 Citations

See all Protein Specific Primary Antibodies

Catalog # Unit Size List Price
44506G 10 blots 299.00

Description

c-RAF [pYpY340⁄341] PAb; Unconjugated Polyclonal antibody specific to Human, (Mouse, Rat) c-Raf [pY340⁄pY341]. This antibody is validated for use in Western Blot,   View full product details >

General Specifications

Reactivity
Rat
Human
Mouse
Validated Application
Western Blot
Immunohistochemistry
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
c-Raf [pYpY340/341]
Gene ID
5894
Label or Dye
Unconjugated
Target Modification State
Phospho
Product Size
10 blots
Purity or Quality Grade
Azide Free
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Cell Analysis
  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
44506G
508e70857940454627ebab8df2957208_CmgtBuyProduct

c-Raf [pS259] Rabbit Polyclonal Antibody

See all Protein Specific Primary Antibodies

Catalog # Unit Size List Price
44502 10 blots 299.00

Description

c-RAF [pS259] PAb; Unconjugated Polyclonal antibody specific to Human, (Mouse, Rat) c-Raf [pS259]. This antibody is validated for use in Western Blot. Anti-c-Raf [pS259] recognizes   View full product details >

General Specifications

Reactivity
Human
Validated Application
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
c-Raf [pS259]
Gene ID
5894
Label or Dye
Unconjugated
Target Modification State
Phospho
Product Size
10 blots
Purity or Quality Grade
Azide Free
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Cell Analysis
  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
44502
dd2a4a45d18fb70e74e7cbd38b6ac1bf_CmgtBuyProduct

c-Raf [pS621] Rabbit Polyclonal Antibody View 1 Citations

See all Protein Specific Primary Antibodies

Catalog # Unit Size List Price
44504G 10 blots 299.00

Description

c-RAF [pS621] PAb hu, (ms, rt) ; Unconjugated Polyclonal antibody specific to Human, (Mouse, Rat) c-Raf [pS621]. This antibody is validated for use in Western Blot. Anti-c-Raf   View full product details >

General Specifications

Reactivity
Human
Validated Application
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
c-RAF [pS621]
Gene ID
5894
Label or Dye
Unconjugated
Target Modification State
Phospho
Purification
Purified
Product Size
10 blots
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Product Applications

  • Drug Discovery & Development
  • Proteins, Expression, Isolation & Analysis
44504G
2c3682bff6a4b63bf07a1c7e0d5eef14_CmgtBuyProduct