Genomics and proteomics search results

RAF1 (cRAF) [Y340D] [Y341D] Recombinant Human Protein

RAF1 (cRAF) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated RAF1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphory ...

Specifications

Form
Frozen
Species
Human
Gene Aliases
RAF1 (cRAF) Y340D Y341D
Kinase Group
Ser⁄Thr Kinases: TKL Group
Accession Number
NP_002871, Y340D, Y341D
Molecular Weight
66.4 kDa
Research Category
Drug Development
Validated Application
Kinase Assay
Protein Tag or Fusion
GST Tag
Expression
Baculovirus
Kinase Family
RAF Kinase Family
Protein Form
Catalytic
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV4046
1372adabbe386cd3bad7615f116fd640_CmgtBuyProduct

RAF1 Kinase Inhibitor I

Raf1 Kinase Inhibitor I is a potent inhibitor of c-Raf1. This compound has been assessed with a number of other enzymes, including Cdk1, Cdk2, c-Src, ERK2, MEK, p38 MAPK, Tie2,VEGFR2, and c-fms, and has been found to be >=100-fold more selective for Raf1. ...

Specifications

Form
Solid
Sterility
Non-sterile
Purification
HPLC
Inhibitor Type
Kinase Inhibitor
Kinase Inhibitor (MAP Kinase Inhibitor)
Molecular Weight
520.9 Da
Inhibitor Properties
Chemical
Specific Inhibitor Target
c-RAF 1
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PHZ1263
928b8d65eefb4c6655767c6a14dc4bbe_CmgtBuyProduct

LanthaScreen® Tb-pMAP2K1 (pSer217⁄221) Antibody Kit

A member of the MAP Kinase family, MAP2K1 (mitogen-activated protein kinase kinase 1) is phosphorylated at Ser217/221 by a range of MAPK family members including Raf and B-Raf. For use in combination with the Fluorescein-MAP2K1 physiological protein substrate (PV4812) to evaluate ...

Specifications

Format
384-well plate
Gene ID
10454, 10746, 1326, 4215, 4217, 4293, 4294, 4296, 5894, 673, 6885
Readout
End Point
Technique
TR-FRET
Reactivity
Human
Label or Dye
FITC (Fluorescein)
Tb (Terbium)
Target Enzyme
Serine⁄Threonine Kinases
Validated Kinases
BRAF, MAP3K2, MAP3K3, MAP3K5, MAP3K7, MAP3K8, MAP3K9, MAP3K10, MAP3K11
Antibody Molecular Weight
150000 Da
Excitation⁄Emission (nm)
340⁄490, 520
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV4813
e855eb49c706e7e710d29bba4250c25f_CmgtBuyProduct

Fluorescein-MAP2K1

Inactive MAP2K1 (MEK1) has been labeled with fluorescein, and is a substrate for MAPK family members. ...

Specifications

Gene ID
10454, 10746, 1326, 4215, 4217, 4293, 4294, 4296, 5894, 673, 6885
Substrate
MAP2K1
Label or Dye
FITC (Fluorescein)
Target Enzyme
Serine⁄Threonine Kinases
Substrate Type
Kinase Substrate
Detection Method
Fluorescent
Molecular Weight
50000 Da
Validated Kinases
BRAF, MAP3K2, MAP3K3, MAP3K5, MAP3K7, MAP3K8, MAP3K9, MAP3K10, MAP3K11
Substrate Properties
Protein-Based Substrate
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV4812
18eee9eb639a078761b0f1e12691a0b9_CmgtBuyProduct

c-RAF Rabbit Polyclonal Antibody, Unconjugated

c-RAF PAb hu, ms, (rt) ; Unconjugated Polyclonal antibody specific to Multiple c-Raf. This antibody is validated for use in Western Blot. Anti-c-Raf recognizes the expressed product of the RAF1 gene, also known as Raf1. Catalog number 44520G is same antibody as former catalog nu ...

Specifications

Reactivity
Mouse
Human
Validated Application
Western Blot
Host
Rabbit
Clonality
Polyclonal
Target Gene
c-Raf
Gene ID
110157, 24703, 5894
Label or Dye
Unconjugated
Purification
Pure
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

44520G
3971e81c2096ec7d8a44dae762ecd408_CmgtBuyProduct

BRAF [V599E] Recombinant Human Protein

BRAF acts upstream of MEK in the MAP kinase pathway and is involved in cell division, differentiation, and secretion. The BRAF mutant V599E is oncogenic and found in a variety of cancers. ...

Specifications

Gene ID
10488, 673
Species
Human
Target Gene
v-raf murine sarcoma viral oncogene homolog B1
Gene Aliases
BRAF V599E
Kinase Group
Ser⁄Thr Kinases: TKL Group
Protein Family
Kinases & Inhibitors
Protein Subtype
Serine⁄Threonine Kinases
Accession Number
NP_004324.1, V599E
Molecular Weight
67.1 kDa
Research Category
Oncology
Signal Transduction
System Compatibility
Z'-LYTE™
LanthaScreen® Antibody
LanthaScreen® Substrate
Validated Application
Kinase Assay
Protein Length or Portion (a.a.)
aa 416-766
Protein Tag or Fusion
GST Tag
Tag Position
N-Terminal
Expression
Baculovirus
Kinase Family
RAF Kinase Family
Protein Form
Catalytic
Recombinant
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

PV3849
f3da3b4a37441c6edec685b12b155fdd_CmgtBuyProduct

BRAF Recombinant Human Protein

BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer, and is thought to play a role in the postsynaptic responses of hippocampal neuron. ...

Specifications

Form
Frozen
Species
Human
Gene Aliases
BRAF, BRAF1
Kinase Group
Ser⁄Thr Kinases: TKL Group
Accession Number
NP_004324.2
Molecular Weight
113.6 kDa
Research Category
Drug Development
Validated Application
Kinase Assay
Protein Tag or Fusion
GST Tag
Expression
Baculovirus
Kinase Family
RAF Kinase Family
Protein Form
Full Length
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

ec4f995dc4a92dfd14aa4e39ff5212e3_CmgtBuyProduct

c-Raf [pYpY340/341] Rabbit Polyclonal Antibody

c-RAF [pYpY340⁄341] PAb; Unconjugated Polyclonal antibody specific to Human, (Mouse, Rat) c-Raf [pY340⁄pY341]. This antibody is validated for use in Western Blot, Immunocytochemistry⁄ Immunofluorescence. Anti-c-Raf [pY340⁄pY341] recognizes the expressed product of the RAF1 gene. ...

Specifications

Reactivity
Mouse
Human
Rat
Validated Application
Immunohistochemistry
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
c-Raf [pYpY340/341]
Gene ID
5894
Label or Dye
Unconjugated
Target Modification State
Phospho
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

44506G
508e70857940454627ebab8df2957208_CmgtBuyProduct

c-Raf [pS259] Rabbit Polyclonal Antibody

c-RAF [pS259] PAb; Unconjugated Polyclonal antibody specific to Human, (Mouse, Rat) c-Raf [pS259]. This antibody is validated for use in Western Blot. Anti-c-Raf [pS259] recognizes the expressed product of the RAF1 gene. ...

Specifications

Reactivity
Human
Validated Application
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
c-Raf [pS259]
Gene ID
5894
Label or Dye
Unconjugated
Target Modification State
Phospho
Shipping Condition
Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

44502
dd2a4a45d18fb70e74e7cbd38b6ac1bf_CmgtBuyProduct

c-Raf [pS621] Rabbit Polyclonal Antibody

c-RAF [pS621] PAb hu, (ms, rt) ; Unconjugated Polyclonal antibody specific to Human, (Mouse, Rat) c-Raf [pS621]. This antibody is validated for use in Western Blot. Anti-c-Raf [pS621] recognizes the expressed product of the RAF1 gene. Catalog number 44504G is same antibody as fo ...

Specifications

Reactivity
Human
Validated Application
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
c-RAF [pS621]
Gene ID
5894
Label or Dye
Unconjugated
Target Modification State
Phospho
Purification
Purified
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

44504G
2c3682bff6a4b63bf07a1c7e0d5eef14_CmgtBuyProduct

Raf-1 Rabbit Polyclonal Antibody

Rabbit anti-Raf-1; Unconjugated Polyclonal antibody specific to Human, Mouse, Rat Raf-1 . This antibody is validated for use in Western Blot, Immunoassay (ELISA). Anti-Raf-1 recognizes the expressed product of the RAF1 gene, also known as Raf1, Raf1. ...

Specifications

Reactivity
Rat
Human
Mouse
Validated Application
Immunoprecipitation
ELISA
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
Raf-1
Gene ID
110157, 24703, 5894
Label or Dye
Unconjugated
Purification
Epitope Affinity Purified
Shipping Condition
Wet Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

712600
859fa608ec949927611de71118630eea_CmgtBuyProduct

c-Raf [pSpY338/340] Rabbit Polyclonal Antibody

c-RAF [pSpY338⁄340] PAb; Unconjugated Polyclonal antibody specific to Human, (Mouse, Rat) c-Raf [pS338⁄pY340]. This antibody is validated for use in Western Blot. Anti-c-Raf [pS338⁄pY340] recognizes the expressed product of the RAF1 gene. Catalog number 44505G is same antibody ...

Specifications

Reactivity
Human
Validated Application
Western Blot
Host
Rabbit
SubClass (Isotype)
IgG
Clonality
Polyclonal
Target Gene
c-Raf [pSpY338/340]
Gene ID
5894
Label or Dye
Unconjugated
Target Modification State
Phospho
Shipping Condition
Approved for shipment on Wet or Dry Ice
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

44505G
3c073df5b53394abf9911e102e843f7a_CmgtBuyProduct

CellSensor® AP-1-bla A375 Cell Line

The CellSensor® AP1-bla A375 cell line contains a beta-lactamase reporter gene under control of the AP1 response element stably integrated into A375 cells. A375 cells are human melanoma cancer cells that contain the endogenous B-Raf mutation V600E resulting in constitutive B-Raf ...

Specifications

System
CellSensor™
Cell State
Dividing Cells
Druggable Target
Signaling Pathway
Regulatory Statement
For Research Use Only. Not for use in diagnostic procedures.

Related Applications

K1660
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