Rabbit anti-Smad4

Manual / Product Insert

Version: 10/08
Catalog #
f499d34bd87b42948b3960b8f6b82e74_Manuals

Mouse anti-Smad4

Manual / Product Insert

Version: 10/08
Catalog #
0ee8b85a85a49346fdff9665312a5cc4_Manuals

Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

Citations & References

  • Authors: Bornstein, S; White, R; Malkoski, S; Oka, M; Han, GW; Cleaver, T; Reh, D; Andersen, P; Gross, N; Olson, S; Deng, CX; Lu, SL; Wang, XJ
  • Journal: JOURNAL OF CLINICAL INVESTIGATION 2009 11:3408-3419
  • ID: PN110631
aebf825f224710bf5838e6826297ea57_Citations

SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway.

Citations & References

  • Authors: Woodford-Richens K L; Rowan A J; Gorman P; Halford S; Bicknell D C; Wasan H S; Roylance R R; Bodmer W F; Tomlinson I P;
  • Journal: Proc Natl Acad Sci U S A (2001) 98:9719-9742
  • ID: PN65251
Catalog #
50ac4b2d6257c591a057a922533f77d5_Citations

Smad4-dependent TGF-β signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells

Citations & References

  • Authors: Zhao, S; Ammanamanchi, S; Brattain, M; Cao, L; Thangasamy, A; Wang, J; Freeman, JW
  • Journal: JOURNAL OF BIOLOGICAL CHEMISTRY 2008 17:11293-11301
  • ID: PN78928
1c7963844aaa8741078058405db5d5eb_Citations

Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity.

Citations & References

  • Authors: Owens P, Bazzi H, Engelking E, Han G, Christiano AM, Wang XJ
  • Journal: Dev Biol 2008 1:156-166
  • ID: PN126113
7961a0fb94e5089213f0f2b05f8ce677_Citations

Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2.

Citations & References

  • Authors: Liang M, Liang YY, Wrighton K, Ungermannova D, Wang XP, Brunicardi FC, Liu X, Feng XH, Lin X,
  • Journal: Mol Cell Biol (2004) 24:7524-7537
  • ID: PN136418
b7ce0c1fcc38750a77f1c2bf55417b52_Citations

Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells.

Citations & References

  • Authors: Müller N, Reinacher-Schick A, Baldus S, van Hengel J, Berx G, Baar A, van Roy F, Schmiegel W, Schwarte-Waldhoff I,
  • Journal: Oncogene (2002) 21:6049-6058
  • ID: PN132758
Catalog #
3c3039ee651de4bb59c1d1066cee3f6b_Citations

Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer

Citations & References

  • Authors: Aitchison, AA; Veerakumarasivam, A; Vias, M; Kumar, R; Hamdy, FC; Neal, DE; Milis, IG
  • Journal: PROSTATE 2008 6:661-674
  • ID: PN79202
35d5c6b689a4bd2db8843f661814fb4b_Citations

Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis

Citations & References

  • Authors: Van Hattem, WA; Brosens, LAA; de Leng, WWJ; Morsink, FH; Lens, S; Carvalho, R; Giardiello, FM; Offerhaus, GJA
  • Journal: GUT 2008 5:623-627
  • ID: PN78666
89cb11cbb1febbdbe6d6af571b3f3125_Citations

Traf2 interacts with Smad4 and regulates BMP signaling pathway in MC3T3-E1 osteoblasts

Citations & References

  • Authors: Shimada, K; Ikeda, K; Ito, K
  • Journal: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2009 3:775-779
  • ID: PN112473
0012b2aed5203803fec32ea4297c20ca_Citations

The up-regulation of 14-3-3 proteins in Smad4 deficient epidermis and hair follicles at catagen

Citations & References

  • Authors: Yuan, C; Jiao, L; Yang, L; Ying, W; Hu, ZS; Liu, JF; Cui, F; Li, L; Qian, LY; Teng, Y; Hang, HY; Qian, XH; Yang, X
  • Journal: PROTEOMICS 2008 11:2230-2243
  • ID: PN81867
67b41e97520341818e0df2b19384fc6f_Citations

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.

Citations & References

  • Authors: Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S,
  • Journal: Cell (2009) 136:123-135
  • ID: PN68861
abb78f41c0c8e19bb91a4295615eae62_Citations

4E-BP1 is a target of Smad4 essential for TGFβ-mediated inhibition of cell proliferation

Citations & References

  • Authors: Azar, R; Alard, A; Susini, C; Bousquet, C; Pyronnet, S
  • Journal: EMBO JOURNAL 2009 22:3514-3522
  • ID: PN111303
5091a0aa85e5a1bf1120fd6183e77bf9_Citations

Smad4/DPC4-dependent Regulation of Biglycan Gene Expression by Transforming Growth Factor-beta in Pancreatic Tumor Cells.

Citations & References

  • Authors: Chen Wen-Bin; Lenschow Wolfgang; Tiede Karen; Fischer Jens W; Kalthoff Holger; Ungefroren Hendrik;
  • Journal: J Biol Chem (2002) 277:36118-36146
  • ID: PN63049
8e1f647f0d7d91df0cf3c7d10b37a236_Citations