Development of high throughput screening assays using fluorescence polarization: nuclear receptor-ligand-binding and kinase/phosphatase assays.

Citations & References

  • Authors: Parker GJ, Law TL, Lenoch FJ, Bolger RE,
  • Journal: J Biomol Screen (2000) 5:77-88
  • Product Usage: An excellent paper demonstrating the utility of FP-based assays in hormone receptor, kinase, and phosphatase activity studies. Estrogen receptors alpha and beta, PCK (multiple isoforms), c-Src, and the tyrosine phosphatase TC-PTP were all examined in these studies. FP-based assays were shown to be suitable for both standard enzyme activity studies, and also high-throughput drug screening.
  • ID: PN43552
Catalog #s
005f91955ff9fc532184ba7566f088fd_Citations