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Powerful molecular testing across the drug development continuum—from preclinical to CDx for oncology

Genomics plays an essential role in oncology drug discovery and companion diagnostic development. The Oncomine® Cancer Research Panel and Workflow* is a fast, easy-to-use next-generation sequencing tool enabling the analysis of hundreds of genes in a single run, providing a universal solution for use in your drug and companion diagnostic development efforts.

Oncomine® Cancer Research Panel and Workflow*—one targeted next-generation sequencing tool for multiple drug and companion Dx development programs

The Oncomine® Cancer Research Panel and Workflow* is based on the proven Ion Torrent™ next-generation sequencing platform and powerful Ion AmpliSeq™ library preparation technology, and also leverages the Oncomine® Knowledgebase, a rich cancer genomics data resource, for target selection, variant calling, and data annotations. Features include:

  • Minimal sample input required per run—making it well suited for analysis of precious tumor samples
  • Generates data for hundreds of important biomarkers in a single run, targeting well-referenced hotspot mutations, CNVs, gene fusions, and indels
  • Easy-to-perform workflow with fast turnaround time—get your NGS data easily and quickly

Learn more below or request to be contacted by a member of our clinical development team

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FFPE Sample

Oncomine® Cancer Research Panel*, Ion 318™ Chip*, and Ion PGM™ System*

Oncomine® Cancer Research Panel Knowledgebase

Starting with nucleic acid extraction from FFPE samples, library preparation is performed with the Oncomine® Cancer Research Panel*, based on proven Ion AmpliSeq™ technology. The highly informative biomarker targets in the panel have been carefully selected by leveraging the expertly curated cancer genomics data within the comprehensive Oncomine® Knowledgebase. Next-generation sequencing is completed quickly and easily using the Ion PGM™ System. The resulting annotated variant data—including hotspot mutations, CNVs, gene fusions, and indels—can be further analyzed using the Oncomine® Cancer Research Panel Knowledgebase, which helps enable users prepare a report meeting their specific laboratory needs.

Discuss the Oncomine® Cancer Research Panel and Workflow* with member of the clinical development team

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Ion AmpliSeq™ technology delivers simple and fast library construction for targeted sequencing of specific human genes or genomic regions. Based on ultrahigh-multiplex PCR, Ion AmpliSeq™ technology requires as little as 10 ng of input DNA or RNA per reaction to target sets of genes, including SNPs, CNVs, gene fusions, and indels, making sequencing of FFPE samples routine on the Ion PGM™ System.

Alternative target selection methods are lengthy and complex and require large amounts (hundreds of nanograms) of DNA, making them less practical for routine sequencing of DNA or RNA from the FFPE tissues commonly used in clinical cancer research, drug, and companion diagnostic development.

Because Ion AmpliSeq™ technology can amplify hundreds of biomarker targets in a single reaction, the Oncomine® Cancer Research Panel* can comprehensively analyze hundreds of the most referenced oncology biomarkers using just 3 primer pools. This not only enables a fast and easy workflow, but also helps ensure that important and actionable—but less prevalent—cancer variants are not missed. 

With the power of Ion AmpliSeq™ technology, the Oncomine® Cancer Research Panel* could become your universal test for multiple oncology drug and companion diagnostic development programs.

Discuss the Oncomine® Cancer Research Panel* with a member of the clinical development team

Ion Torrent™ NGS platform is the solution to advance oncology drug and companion diagnostic development

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Learn more about Ion Torrent™ next-generation sequencing technology.

The Ion PGM™ System combines semiconductor sequencing technology with natural biochemistry to directly translate chemical information into digital data. The system’s use of simple, natural sequencing chemistry eliminates the need for complicated optics and detection systems, democratizing sequencing and making it accessible to virtually any laboratory, and reduces complex chemistries to measure natural DNA extension. Direct, real-time sequencing detection provides sequencing results typically in less than 3 hours.

Discuss the Oncomine® Cancer Research Panel* and Ion PGM™ System with a member of our clinical development team

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Oncomine® Cancer Research Panel Knowledgebase Data Tables

Oncomine® Cancer Research Panel Knowledgebase Reported Summaries

Oncomine® Cancer Research Panel Knowledgebase

To inform and drive drug discovery and companion diagnostic development programs, the vast genomic data sets produced by next-generation sequencing studies must be analyzed, annotated, and, ultimately, interpreted by experienced bioinformaticians. The Oncomine® Knowledgebase, the world’s largest curated compendium of cancer genomic information, is a database of integrated cancer genomics data with exceptional attention to detail. The Oncomine® Knowledgebase was an instrumental tool in the selection of targets and the development of the Oncomine® Cancer Research Panel*.

Powered by the Oncomine® Knowledgebase, the Oncomine® Cancer Research Panel Knowledgebase was developed specifically for further examination of next-generation sequencing data generated from samples analyzed using the Oncomine® Cancer Research Panel and Workflow*. Users may subsequently use this information to create data summaries and reports appropriate for their needs.

The Oncomine® Cancer Research Panel Knowledgebase is a curated set of published evidence from clinical trials that supports the matching of driver genetic variants with relevant potential clinical therapeutic options, such as published therapeutic interventions and clinical trials. The Oncomine® Cancer Research Panel Knowledgebase is comprised of two component tools:

  • Oncomine® Cancer Research Panel Knowledgebase Data Tables
    • 3 data lookup tables in tab separated (.TSV) file format
    • Oncomine® driver, prevalence, and actionability content for individual variants
  • Oncomine® Cancer Research Panel Knowledgebase Reported Summaries
    • Pre-rendered supplementary information tables in PDF format
    • Summary files for variant actionability class and cancer type

Discuss the Oncomine® Cancer Research Panel Knowledgebase with member of the clinical development team

*For Research Use Only. Not for use in diagnostic procedures.