CaptureSelect™ ligands and affinity chromatography resins can be used for the highly efficient capturing step for a variety of Biopharmaceuticals.

Selectivity

  • high purity in single step/feed stock independent

Mild elution conditions

  • retaining biological activity of target

Reduction of process steps

  • higher yields, reduced costs

Efficient clearance of HCP, DNA, virus

  • high selectivity in capture step

We offer products for large scale purification of various biologics such as antibodies and antibody fragments, fusion proteins and hormones.

We also offer complementery leakage ELISA.

CaptureSelect™ affinity matrices from Life Technologies:

Product Target applications Uniqueness

CaptureSelect™ IgG-CH1

Human IgG antibodies and Fab fragments thereof

CH1 domain binding, no free light chain binding for fragments

CaptureSelect™ KappaXL Human IgG antibodies and Fab fragments thereof containing a kappa light chain Mild elution for fragments and antibodies
CaptureSelect™ FcXL Human IgG antibodies and Fc-fusion proteins CH3 domain binding, human specific, recognizing all four subclasses, mild elution conditions

CaptureSelect™ FSH

Human Follicle Stimulating Hormone

Binds only intact FSH due to alpha/beta chain epitope

CaptureSelect™ hGH

Human growth hormone

High purity capture from E.coli

CaptureSelect™ HSA

Human serum albumin, albumin fusion proteins

Mild elution conditions,

CaptureSelect™ IgA

Human IgA, s-IgA

Platform for IgA

POROS® CaptureSelect™ IgM

Human IgM

Platform for IgM

View additional CaptureSelect™ products


 

Contact a member of our business development team to discuss possibilities for further development of these products.

CaptureSelect™ information

 

Other CaptureSelect™ affinity matrices:

Product Target application Product information downloads
IXSelect High-throughput medium specificallydesigned for the purification of factor IX targets from various feed streams

IgSelect

For purification of IgG1, IgG2, IgG3 and IgG4 from any source. Human specific, making it extremely suitable for the purification of monoclonals from transgenic sources or IVIG from plasma.

KappaSelect

Plug and play purification of any antibody format containing the kappa light chain, including antibody fragments, IgM, IgA and IgG’s in a single step process.

AVB Sepharose High Performance

Scalable solution to purify Adeno-Associated Virus serotypes 1, 2, 3, 5, 8 in a single step process to a high degree of purity while retaining infectivity.

VIIISelect

A product developed for the purification of recombinant b-domain deleted Factor VIII offering high yield and purity in a single-step.

Alpha-1 AntitrypsinSelect

A product developed for the purification of human AAT from different sources such as, recombinant, plasma derived and transgenically produced AAT.

VIISelect

A product developed for the purification of both plasma derived as well as recombinantly produced human Factor VII / Factor VIIa

LambdaFabSelect

Plug and play purification of any antibody format containing the lambda light chain, including antibody fragments, IgM, IgA and IgG’s in a single step process.

GCSFSelect

An affinity medium designed for the purification of G-CSF products derived from E.coli, rendering high purity and yield in one step

These resins are available from GE Healthcare

CaptureSelect™ Leakage ELISAs

Products incorporating CaptureSelect™ technology have already been developed and are used for clinical and commercial manufacturing of a variety of Biologicals. To support these products Life Technologies has developed product specific Leakage ELISAs that can be used for routine quality analysis. Below a list of leakage ELISAs and their corresponding affinity resins.

Product Complementing resin

CaptureSelect™ IgG-CH1 Ligand Leakage ELISA

CaptureSelect™ IgG-CH1

CaptureSelect™ FSH Ligand Leakage ELISA

CaptureSelect™ FSH

CaptureSelect™ KappaXL Ligand Leakage ELISA

CaptureSelect™ KappaXL

CaptureSelect™ IgM Ligand Leakage ELISA

POROS® CaptureSelect™ IgM

CaptureSelect™ HSA Ligand Leakage ELISA

CaptureSelect™ HSA

CaptureSelect™ FcXL Ligand Leakage ELISA

CaptureSelect™ FcXL

CaptureSelect™ AAV9 ligand leakage ELISA

POROS® CaptureSelect™ AAV9

IgSelect leakage assay

IgSelect*

KappaSelect leakage assay

KappaSelect*

AVB Sepharose HP leakage assay

AVB Sepharose High Performance*

VIIISelect leakage assay

VIIISelect*

Alpha-1 Antitrypsin leakage assay

Alpha-1 AntitrypsinSelect*

VIISelect leakage assay

VIISelect*

LambdaFabSelect leakage assay

LambdaFabSelect*

IXSelect leakage assay

IXSelect*

GCSFSelect leakage assay

GCSFSelect*

* These chromatography resins, based on the CaptureSelect™ technology, have all been developed in collaboration with GE Healthcare and are currently in use for clinical and commercial manufacturing of biological compounds.