The CaptureSelect™ affinity product line delivers a range of research products for every step in the development process, from discovery research to preclinical purification. Life science research products are available as slurries from 5 mL to 1 L and can be made available for high-throughput screening and as pre-packed columns.

These products were developed by BAC BV, a company acquired by Life Technologies in early 2013. Now, all CaptureSelect® products are available from Life Technologies.

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Antibody purification: Virtually any antibody format can be purified with Antibody Toolbox® products, ranging from specific human IgG and antibody fragment purification, IgMs, rodent IgGs without co-purifying bovine IgGs. Unlike the common bacterial coat protein matrices (Protein A, G, and L) they are specifically designed to purify any antibody format with high affinity and specificity. The products are immobilized on high-capacity agaroses.

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Protein purification: These single-step purification products are immobilized on high-capacity agaroses and are used for purification of selected therapeutic proteins or fusion proteins. CaptureSelect™ protein purification products can be used in affinity chromatography settings to efficiently purify biopharmaceuticals. CaptureSelect™ C-tag, a novel affinity tag system offering the unique selectivity for a small 4 amino acid peptide tag: E-P-E-A (glutamic acid - proline - glutamic acid - alanine), which enables simple purification of C-tagged proteins. The opportunity to use a single-step purification process makes these products ideal for consideration for cost-effective production of biosimilars.

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Sample preparation: The sample preparation products in the Proteomics Toolbox® line are single-domain monospecific antibodies immobilized on high-capacity agarose-based beads, and are individually tested for specific binding to human plasma proteins. They are designed for single-step, single-use depletion of highly abundant proteins from human serum, plasma, and cerebrospinal fluid with the highest reported loading capacity. The single-use concept eliminates the need for re-use and avoids the cross-contamination of samples that can result from that practice. The products are used for sample preparation before gel electrophoresis, mass spectrometry in biomarker discovery and validation, and as a sample preparation step before clinical diagnostics.

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Ligand conjugates: A selection of CaptureSelect™ ligands have been chemically conjugated to biotin for use in analytical assays. From IgG to IgM to lambda and kappa light chains, biotinylated CaptureSelect™ ligands enable a whole range of novel selectivities for antibody analytics.

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