CaptureSelect™ Antibody Toolbox® products offer:

  • Unique selectivity
  • High purity in a single step
  • Increased yield
  • Flexible formats
  • Species specificity
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CaptureSelect™ Antibody Toolbox® products are designed to enhance the success of your antibody purification processes. The products offer specific advantages over purification using Proteins A, G, and L, including unique target specificity and simplified elution protocols. Each product has defined target specificity for distinct antibody types and regions, minimizing the need for you to test multiple media products to determine the optimal choice.




Single-step purification of many antibody formats

Many kinds of antibody formats can be purified with one of our Antibody Toolbox® products. Unlike the common bacterial coat protein matrices, Proteins A, G, and L, CaptureSelect™ ligands are developed with defined specificity and high avidity to the target protein of interest. This results in affinity chromatography resins well suited for single-step protein purification.

CaptureSelect™ Antibody Toolbox® resins for biomolecule purification

IgG all sublasses Characteristics
CaptureSelect™ IgG-CH1 (resin) Suitable for purification of human IgG and all Fab fragments
CaptureSelect™ IgG-CH1 (pre-packed column) Suitable for purification of human IgG and all Fab fragments
CaptureSelect™ FcXL Specific for human IgG, recognizing all four subclasses, offering mild elution conditions
CaptureSelect™ IgG-Fc (Hu) Specific for human IgG, recognizing all four subclasses
CaptureSelect™ IgG-Fc (ms) Designed to purify IgG from multiple species by high affinity binding to the Fc region of IgG’s

Light chains Characteristics
CaptureSelect™ KappaXL To purify all human kappa Ig light chain containing products, offering mild elution conditions
CaptureSelect™ LC-kappa (Hu) To purify all human kappa Ig light chain containing products
CaptureSelect™ LC-kappa (mur) Murine Ig binder recognizing IgG, IgM, IgA, IgD, IgE, Fab fragments, Poly Ig from mouse, rat and guinea pig
CaptureSelect™ LC-lambda (Hu) To purify all human lambda Ig light chain containing products
CaptureSelect™ LC-lambda (ung) Suitable for Ig’s, Fab fragments and free light chains from ungulates (bovine, horse, donkey, sheep, goat, pig)
CaptureSelect™ LC-lambda (mouse) Mouse Ig binder recognizing IgG, IgM, IgA, IgD, IgE, Fab fragments containing a lambda light chain
CaptureSelect™ LC-lambda (rat) Ig binder recognizing IgG, IgM, IgA, IgD, IgE, Fab fragments containing a lambda light chain from Rat and Guinea Pig

Isotype specific Characteristics
CaptureSelect™ IgM IgM resin suitable for human, mouse and rat IgM's
CaptureSelect™ IgA For purification of human IgA, IgA-dimers and secretory IgA (sIgA)
CaptureSelect™ IgA-CH1 (Hu) For purification of human IgA, IgA-dimers and secretory IgA (sIgA) and Fab fragments thereof

IgG subclass specific Characteristics
CaptureSelect™ IgG4 (Hu) Specific for human IgG4 without any crossbinding to other subclasses or species
CaptureSelect™ IgG1 (Hu) Specific for human IgG1 without any crossbinding to other subclasses or species
CaptureSelect™ IgG3 (Hu) Specific for human IgG3 without any crossbinding to other subclasses or species

*A selection of the species that have been tested. Refer to the product sheet for more detailed information.

Hu = human, Pr = primates, Bo = Bovine, Hr = Horse, Gt = goat, Sh = sheep, Do = donkey, Gp = guinea pig, Mo = mouse, Rb = rabbit, Ch = chicken, ms = multi species, mur = murine, ung = ungulate

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Resources

Antibody purification Literature