Antibodies for Epigenetics

Unlock the Mysteries of the Epigenetic Code

Read, write, and erase the epigenetic code with confidence using the first-ever master set of highly specific recombinant epigenetic antibodies developed in conjunction with the Structural Genomics Consortium. Get peak specificity and performance every time in every lot.

This antibody master set for epigenetics research is setting the standard for specificity, sensitivity, and consistency.

Recombinant Epigenetic Antibodies

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Recombinant Antibodies for Epigenetic Research

Epigenetic regulatory proteins are involved in a wide variety of chronic diseases, such as cancer, and are the target of an explosive new field of drug discovery. The ability to properly study most epigenetic changes, which determine which genes are “turned off and on,” is determined by the effectiveness of one critical tool—antibodies. To date, most antibody targets are directed to histone modifications that have led to an increased understanding of the role of epigenetics in various cellular processes. The limited availability of antibodies targeting the readers, writers, and erasers of the epigenetic code, along with a lack of industry-wide standards for antibody quality, has plagued the study of these proteins, leading to an influx of antibodies that do not perform consistently or with the promised specificity.

Life Technologies and the Structural Genomics Consortium collaborate on the first antibody master set to read, write, and erase the epigenetic code

Life Technologies has formed a collaborative partnership with leading epigenetic experts through the Structural Genomics Consortium (SGC), a network of more than 200 scientists from the Universities of Chicago, Toronto, and Oxford, as well as partners from the pharmaceutical companies Abbott, Eli Lilly, GlaxoSmithKline, Novartis, Pfizer, and Takeda. These leading scientists in antibody technology have joined forces to design and generate the first-ever master set of recombinant epigenetic antibodies targeting the readers, writers, and erasers of the epigenetic code. The first of 200 highly specific recombinant monoclonal antibodies are now available (Table 1) to provide you with the consistency that can only be achieved with recombinant technology.

“The [Life Technologies/SGC] partnership is prepared to produce a set of 200 highly specific, highly sensitive antibodies that are validated for specific applications,” says Dr. Aled Edwards, Director and CEO of SGC. “These antibodies now being launched are the first step toward developing the de facto standard set of quality epigenetics antibodies that researchers can use for generations to come.”

Each of the recombinant monoclonal antibodies in this master set are derived by isolating the clones of antibody heavy and light chains that have been carefully tested for their sensitivity and selectivity, and then expressing these clones in mammalian cells. Because recombinant antibodies are produced from renewable and stable clones, they provide peak specificity and performance with every lot. Furthermore, these recombinant antibodies are selected and validated for specific applications, including immunoprecipitation and western blotting, representing a significant improvement over existing antibodies on the market today.

Table 1: Targets for the Life Technologies/SGC antibody master set and for the ChIP-validated antibodies.

Targets for Life Technologies/SGC epigenetics antibodies released to date*

ATAD2B (Monoclonal)L3MBTL1 (Monoclonal)SETD7  (Monoclonal)
ATAD2  (Monoclonal)L3MBTL2 (Monoclonal)SETMAR  (Monoclonal)
ATAD2  (Biotinylated Fab) L3MBTL2 (Biotinylated Fab)SFMBT1  (Monoclonal)
BAZ1B  (Biotinylated Fab)L3MBTL3  (Monoclonal)SFMBT2  (Monoclonal)
BAZ2B  (Monoclonal)L3MBTL3   (Biotinylated Fab)SFMBT2 (Biotinylated Fab)
BAZ2B (Biotinylated Fab)L3MBTL4 (Monoclonal)SMARCA2 (Monoclonal)
BRD3  (Monoclonal)L3MBTL4  (Biotinylated Fab)SMARCA4 (Monoclonal)
BRD4 (Monoclonal)MBTD1  (Monoclonal)SMARCA4 (Biotinylated Fab)
BRD4 (Biotinylated Fab)MBTDI  (Biotinylated Fab)SMYD3  (Monoclonal)
BRD7 (Biotinylated Fab)    MEN1 (Monoclonal)SUV420H2  (Monoclonal)
BRD7 (Monoclonal)MEN1  (Biotinylated Fab)SUV39H1 (Biotinylated Fab)
CBX1 (Monoclonal)PARP14  (Biotinylated Fab)TAF1 (Monoclonal)
CBX1  (Biotinylated Fab)PB1A  (Monoclonal)TAF1A  (Monoclonal)
CBX2 (Monoclonal)PRBM1 (Monoclonal)TDRD3 (Recombinant)
CBX3 (Monoclonal)PRDM4 (Recombinant)TDRD3 (Monoclonal)
CBX3 (Biotinylated Fab)PRDM4 (Monoclonal)TDRD3 (Biotinylated Fab)
CBX5 (Monoclonal)PRDM4 (Biotinylated Fab)TDRKH  (Monoclonal)
CBX5 (Biotinylated Fab)PRDM9  (Monoclonal)TOPK (Monoclonal)
CECR2  (Monoclonal)PRDM9  (Biotinylated Fab)TOPK (Biotinylated Fab)
EHMT1  (Monoclonal)PRDM10 (Monoclonal)TRIM28  (Monoclonal)
EP300 (Monoclonal)PRMT3 (Monoclonal)TSC2 (Recombinant)
EP300  (Recombinant)PRMT3  (Biotinylated Fab)TSC2 (Biotinylated Fab)
EP300 (Biotinylated Fab)PRMT5  (Monoclonal)TSC2 (Monoclonal)
FALZ/FALZA (Monoclonal)SCML2  (Monoclonal)WDR5 (Monoclonal)
KDM5C  (Monoclonal)SETD3  (Monoclonal)WHSC1L1 (Monoclonal)

 

Targets for ChIP-validated antibodies

CIITAH3K79me2HDAC2 Pol II
ENX-1/EZH2H3K79me3HDAC3 PPAR-γ (clone A3409A)
Estrogen receptor-α H3K9/14acHepatocyte nuclear factor-4α PPAR-γ (clone K8713)
H3K27me1H3K9achGRRetinoid X receptor-α
H3K27me2H3K9acS10pHIST3H3TDRKH
BRD4 (Biotin conjugate)L3MBTL3 (Biotin conjugate)HIST3H3Sox2
H3K27me3H3K9me1HIST3H3 (Methylated)STAT3
H3K27me3S28p H3K9me2 HIST3H3 (Phospho)STAT4
H3K36me3H3K9me3MBD1STAT5-ϐ
H3K4me1H3R17me2MECP2Suz12
H3K4me2H4K20me3NF-YBTBP
H3K4me3H4K8acp53TIP5
H3K79me1HDAC1  


*Antibodies not listed in the ChIP-validated set have been validated for target-protein immunoprecipitation (IP) but not yet for ChIP. Updated application information on individual antibodies can be found on our website.

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