Precise genome engineering is here

GeneArt® Precision TALs provide custom DNA-binding proteins for accurate DNA targeting and precise genome editing. Unlike other technologies that limit the choice of targets, or provide ambiguous results, GeneArt® Precision TALs enable the targeting of any locus in the genome.

  • Precise—technology that recognizes the DNA sequence you specify
  • Flexible—you choose the effectors and Gateway® technology–compatible vector that meet your needs
  • Reliable—the final clone contains a verified, optimized sequence for improved expression
  • Fast—receive your clone (order) typically within 2 weeks after your order has been confirmed

GeneArt® Precision TALs offer site-specific delivery of nucleases, activators, repressors, chromatin modifiers, genomic labels, and cross-linking molecules. This genome editing technology is known to function in a variety of host systems, including bacteria, yeast, plants, insects, zebrafish, and mammals. Speak with a TALs specialist

Order your TALs today

NEW! GeneArt® Precision TAL-edited cell line service now available.

Detect locus-specific double-strand breaks

The GeneArt® Genomic Cleavage Detection Kit offers a simple, reliable, and rapid method for detection of locus-specific double-strand break formation. The assay provides the efficiency at which genome editing tools such as CRISPRs, TALs, and zinc finger nucleases cleave at a given locus. This cleavage is easily detectable and quantifiable using gel analysis

Silencer Select siRNA for a genome-wide screen resulted in new Parkinson’s disease targets

This Nature publication from NCATS, NIH demonstrates the utility of Silencer Select Genome-Wide siRNA library for arrayed high throughput screening in effectively identifying novel drug targets for Parkin’s disease. The workflow adopted for this effort also was dependent on other Life Technology products such as Lipofectamine RNAiMAX and Gibco Media for its success. Final validation of lead drug targets was accomplished by creating knockout cell lines using the TAL-effector endonuclease (TALEN) technology.

Read the article here:

Functionality selection guide

Additional resources

GeneArt® Precision TALs user manual

Video on TALs technology

Watch this online tutorial, presented by Dr. Jon Chesnut, Research Fellow and R&D lead, to learn more about GeneArt® Precision TALs technology.

Maximize the efficiency of genetic modifications

Use Lipofectamine 3000  to improve the cleavage efficiency with GeneArt Precision TALs or CRISPR. Download the Application Note here.