Building the Cell Model
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects 1% of people over age 60 and more than 5 million individuals worldwide. We have collaborated with The Parkinson’s Institute in Sunnyvale, California, to demonstrate how to develop cellular models to identify drugs that may ameliorate the underlying processes of PD, or to understand the environmental factors that impact the development of PD.
Watch Dr. Birgitt Schuele’s presentation on the collaboration with The Parkinson’s Institute
Download the white papers
In a series of white papers, we describe three steps for creating PD cell models using Life Technologies tools:
Generating iPSCs (paper 1)Creating the model systems using donor fibroblasts collected at The Parkinson’s Institute to generate induced pluripotent stem cells (iPSCs), and then characterizing the iPSCs to confirm successful reprogramming.
NSCs from donor-derived iPSC lines (paper 2)Generating and characterizing neural stem cells (NSCs) from the PD donor-derived iPSC lines, and then differentiating the NSCs to dopaminergic neurons or other relevant cell types to study the associated cell types involved in PD.