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Invitrogen offers a collection of in vitro ADMETox tools for drug discovery and development, including GIBCO® hepatocytes, microsomes, and transporter products to help you determine the metabolic and safety profiles of lead candidates.

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ADME/Tox Products

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GIBCO® Hepatocytes

Fresh human & animal, cryopreserved human & animal, and cell culture reagents

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Transporter Products

GenoMembrane Transporter Vesicles and Transporter-qualified Hepatocytes

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Toxicology Products

Assays to identify indicators of both biochemical and cellular toxicity

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Nuclear Receptor ADME Assays

Our LanthaScreen® PXR (SXR) and CAR Competitive Binding Assays contains all the reagents you need to conduct compound affinity testing

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PCR-Based Drug Discovery Assays

Analyze drug discovery-related genes using our real-time PCR arrays

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Hepatic Systems

HepaRG™ cells, hepatic co-cultures and non-parenchymal cell products

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Liver Microsomes

Large pooled lots for long-term studies tested for select CYP450 & phase II enzyme activities

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P450 Assays

Fluorescent substrates and recombinant enzymes to evaluate your compound’s potential impact on P450 activity

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G-Protein Coupled Receptor Cellular ADME Assays

Avoid off-target effects with our GPCR toxicity panel of validated cellular assays for selectivity screening

For Research Use Only. Not for use in diagnostic procedures.