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Frequently Asked Questions
Answers to many of the questions you might have about ADME/Tox products, with tips and tricks for success.
What is a Rapid Alert?
Rapid Alerts notify you of the impending availability of fresh primary human hepatocytes. Note: fresh hepatocytes available in North America only. Upon receiving a Rapid Alert email, you decide if you need hepatocytes for an upcoming study and can contact us immediately to place an order. Sign up to receive our Rapid Alert.
- a summary of the donor’s demographics, such as gender, age, race, BMI, and history of alcohol, drugs, or medications
- the plate and suspension formats available for order
- the date when the hepatocytes will be shipped to you
- a phone number and email to place your order or request additional information
How should I handle the fresh hepatocytes once I receive them?
Upon receipt, fresh hepatocytes in suspension should be centrifuged at 4ºC immediately, following our instructions. Plated hepatocytes should be quickly removed from the box and the shipping medium replaced with fresh culture medium.
After thawing, how long can hepatocytes be kept in culture?
Unlike immortalized cell lines, hepatocytes are primary cells that cannot be cultured indefinitely. The use of thawed suspension hepatocytes should be limited to short-term experiments with a maximum of 4-6 hour incubations.
Get the most out of your hepatic products through our protocols and user guides. Obtain the latest literature published by both Life Technologies scientists and thought leaders in the ADME/Tox research field.
Learn more about:
- Organotypic Liver Culture Models: Meeting current challenges in toxicity testing
- In Vitro Assessment of Metabolic Drug–Drug Interaction Potential of AZD2624, Neurokinin-3 Receptor Antagonist, Through Cytochrome P(450) Enzyme Identification, Inhibition, and Induction Studies.
- Differential Effect of Meclizine on the Activity of Human Pregnane X Receptor and Constitutive Androstane Receptor.
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