The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. Invitrogen’s experienced team of GPCR biologists has generated a highly validated and novel family of GPCR cell line products to enable your discovery programs.

The portfolio contains two distinct assay platforms each utilizing FRET as the assay readout: Tango™ GPCR cell lines and GeneBLAzer® GPCR cell lines. Each GPCR cell line platform is available in two cell states: Division Arrested non-dividing cells and normal dividing cells. Click through our cell line product table below and capability links to the right to see how we can help accelerate your drug discovery efforts.

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Assay Performance Data Dividing Cells Division Arrested Cells Available in
Family Receptor Geneblazer® Technology Tango™ Technology Catalog no. Catalog no. SelectScreen™ Service Confirmed  Readout
Acetylcholine (Muscarinic) M1   K1710     Ca²+(Fluo-4)
Acetylcholine (Muscarinic) M1     K1735 K1365              X Ca²+(Fluo-4), Phospho-ERK2
Acetylcholine (Muscarinic) M1  
K1861     Ca²+(Fluo-4), Phospho-ERK2
Acetylcholine (Muscarinic) CHRM2 (M2)   PDF Download K1564   X Ca²+(Fluo-4)
Acetylcholine (Muscarinic) M3 PDF Download   K1716   X Ca²+(Fluo-4)
Acetylcholine (Muscarinic) M4 PDF Download   K1741   X Ca²+(Fluo-4)
Acetylcholine (Muscarinic) M4     K1818   X Phospho-ERK2
Acetylcholine (Muscarinic) M5 PDF Download   K1728   X Ca²+(Fluo-4)
Adenosine ADORA1   PDF Download K1445 K1601 X  
Adenosine ADORA2A PDF Download   K1530 K1345   cAMP
Adenosine ADORA2B     K1780      
Adenosine ADORA3     K1837      
Adrenoreceptor ADRA1A PDF Download   K1470 K1577 X Ca²+(Fluo-4)
Adrenoreceptor ADRA1B PDF Download   K1471   X Ca²+(Fluo-4)
Adrenoreceptor ADRA2A PDF Download   K1743   X Ca²+(Fluo-4)
Adrenoreceptor ADRA2A   PDF Download K1604 K1607 X  
Adrenoreceptor ADRB1 PDF Download   K1553   X cAMP
Adrenoreceptor ADRB2 PDF Download   K1472     cAMP, ERK2
Adrenoreceptor ADRB3 PDF Download   K1745 K1473 X cAMP
Angiotension AGTR1     K1443   X Ca²+(Fluo-4), Phospho-ERK2
Angiotension-Like AGTRL1   PDF Download K1754 K1762 X  
Bradykinin BDKRB1 PDF Download   K1734 K1363 X Ca²+(Fluo-4),
Phospho-ERK2
Bradykinin BDKRB2 PDF Download   K1790   X  
Calcitonin CALCR PDF Download   K1480   X cAMP
Calcitonin CALCRL: RAMP1 PDF Download   K1437   X cAMP
Calcitonin CALCRL: RAMP2 PDF Download   K1438     cAMP
Calcitonin CALCRL: RAMP3 PDF Download   K1439   X cAMP
Calcium Sensing CASR     K1833   X Ca²+(Fluo-4)
Cannabinoid CNR1   PDF Download K1513   X  
Cannabinoid CNR2   PDF Download K1512 K1567 X  
Chemokine CXCR1   PDF Download K1807   X  
Chemokine CXCR2   PDF Download K1521   X  Ca²+(Fluo-4)
Chemokine CXCR3   PDF Download K1829   X  Ca²+(Fluo-4)
Chemokine CXCR4     K1779   X  Ca²+(Fluo-4)
Chemokine CXCR6   PDF Download K1563   X  
Chemokine CXCR7   PDF Download K1832   X  
Chemokine CCR1   PDF Download K1787 K1793 X  Ca²+(Fluo-4)
Chemokine CCR2   PDF Download K1809   X  
Chemokine CCR3   PDF Download K1815   X  
Chemokine CCR4   PDF Download K1799                X  Ca²+(Fluo-4)
Chemokine CCR5   PDF Download K1788   X Phospho-ERK2, Ca²+(Fluo-4)
Chemokine CCR6   PDF Download K1761 K1765 X  
Chemokine CCR7   PDF Download K1531   X Phospho-ERK2,
Ca²+(Fluo-4)
Chemokine CMKLR1   PDF Download K1527 K1551 X  
Cholecystokinin CCKAR PDF Download   K1548 K1623 X Ca²+(Fluo-4), Phospho-ERK2
Cholecystokinin CCKBR PDF Download   K1742 K1379 X Ca²+(Fluo-4)
Complement Component C5AR1 PDF Download   K1746 K1554 X Ca²+(Fluo-4)
Corticotropin Releasing Factor CRHR1 PDF Download   K1736 K1367 X cAMP
Corticotropin Releasing Factor CRHR2 PDF Download   K1733   X cAMP
Assay Performance Data Dividing Cells Division Arrested Cells Available in
Family Receptor Geneblazer® Technology Tango™ Technology Catalog no. Catalog no. SelectScreen™ Service Confirmed Readout
Dopamine D1 PDF Download K1485 cAMP
Dopamine D2 K1708 X Ca²+(Fluo-4),
Phospho-ERK2
Dopamine D5 PDF Download K1784     Ca²+(Fluo-4)
Endothelial Differentiation Gene EDG1   PDF Download K1520   X  
Endothelial Differentiation Gene EDG2   PDF Download K1519   X  
Endothelial Differentiation Gene EDG3 PDF Download   K1713 K1319 X Ca²+(Fluo-4)
Endothelial Differentiation Gene EDG3     K1848     Ca²+(Fluo-4)
Endothelial Differentiation Gene EDG4   PDF Download K1442   X  
Endothelial Differentiation Gene EDG6   PDF Download K1622 K1757 X  
Endothelial Differentiation Gene EDG7 PDF Download
K1511 K1315 X Ca²+(Fluo-4)
Endothelial Differentiation Gene EDG7
PDF Download K1849   X Ca²+(Fluo-4)
Endothelial Differentiation Gene EDG8   PDF Download K1518   X  
Endothelin EDNRA   K1726 K1347 X Ca²+(Fluo-4)
Endothelin EDNRA   PDF Download K1444   X  
Endothelin EDNRB PDF Download   K1727 K1349 X Ca²+(Fluo-4)
Formyl Peptide-Like FPRL-1 PDF Download   K1532 K1357 X Ca²+(Fluo-4)
Galanin GALR1   PDF Download K1616   X  
Galanin GALR2   PDF Download K1811   X  
Gastrin Releasing Peptide GRPR PDF Download   K1561 K1637 X  
Ghrelin GHSR     K1819   X Ca²+(Fluo-4)
Gastric Inhibitory Polypeptide GIPR
  K1864   X  
Glucagon GCGR     K1855   X cAMP
Glucagon GLP1R   K1783   X cAMP
Glucagon GLP2R   PDF Download K1543   X cAMP
Gonadotropin Releasing Hormone GnRHR PDF Download   K1854   X Ca²+(Fluo-4)
Histamine H1 PDF Download   K1703 K1299 X Ca²+(Fluo-4)
Histamine H2 PDF Download   K1707 K1307 X cAMP
Histamine H3   PDF Download K1466 K1509 X  
Histamine H4   PDF Download K1465   X Ca²+(Fluo-4)
KiSS1 GPR54 PDF Download   K1720 K1333 X Ca²+(Fluo-4)
Leukotriene LTB4R PDF Download   K1748   X Ca²+(Fluo-4)
Melanin-concentrating Hormone MCHR1 (GPR24) PDF Download   K1730   X Ca²+(Fluo-4)
Melanin-concentrating Hormone MCHR2 (GPR145) PDF Download   K1852   X Ca²+(Fluo-4)
Melanin-concentrating Hormone MCHR2 (GPR145)   PDF Download K1836   X Ca²+(Fluo-4),
Phospho-ERK2
Melanocortin MC1R PDF Download   K1724 K1341 X cAMP
Melanocortin MC2R PDF Download   K1483 K1597 X  
Melanocortin MC3R PDF Download   K1744 K1423 X cAMP
Melanocortin MC5R PDF Download   K1740   X cAMP
Melatonin MTNR1A   PDF Download K1669   X  
Melatonin MTNR1B   PDF Download K1753   X  
Motilin MLNR   PDF Download K1862      
Neuropeptide B/W GPR8   PDF Download K1478   X  
Neuropeptide S NPSR1a PDF Download   K1447 K1493 X Ca²+(Fluo-4)
Neuropeptide S NPSR1b PDF Download   K1481   X Ca²+(Fluo-4)
Neuromedin U NMUR1 PDF Download   K1719   X  
Neurotensin NTSR1 PDF Download   K1781 K1773 X Ca²+(Fluo-4)
Neuropeptide Y NPY1R   PDF Download K1803   X  
Neuropeptide Y NPY2R   PDF Download K1479 K1501 X  
Neuropeptide Y NPY5R   PDF Download K1782      
    Assay Performance Data Dividing Cells Division Arrested Cells Available in
Family Receptor Geneblazer® Technology Tango™ Technology Catalog no. Catalog no. SelectScreen™ Service Confirmed Readout
Nicotinic Acid GPR109A   PDF Download K1791   X  
Opioid OPRD1   PDF Download K1778   X  
Opioid OPRM1   PDF Download K1523 K1599 X  
Opioid OPRK1 PDF Download   K1533   X Ca²+(Fluo-4). Phospho-ERK2
Opioid OPRK1   PDF Download K1576   X Phospho-ERK2
Opioid OPRL1 PDF Download   K1714   X Phospho-ERK2
Opioid OPRL1   PDF Download K1786   X Ca²+(Fluo-4),
Phospho-ERK2
Orexin HCRTR1 PDF Download   K1446   X Ca²+(Fluo-4)
Orexin HCRTR2 PDF Download   K1737 K1369 X Ca²+(Fluo-4)
Platelet Activating Factor PTAFR   PDF Download K1789   X Ca²+(Fluo-4)
Prokineticin PROKR2 PDF Download   K1856      
Prolactin Releasing Peptide GPR10 PDF Download   K1732   X Ca²+(Fluo-4)
Prostanoid PTGDR PDF Download   K1739 K1373 X cAMP
Prostanoid CRTH2 (GPR44)   PDF Download K1859   X  
Prostanoid PTGER1 PDF Download   K1851   X  
Prostanoid PTGER2 PDF Download   K1723   X cAMP
Prostanoid PTGIR PDF Download   K1850   X  
Prostanoid TBXA2R   PDF Download K1549   X Ca²+(Fluo-4), Phospho-ERK2
Protease Activated F2RL1   PDF Download K1830   X  
P2Y (Purinergic/
Pyrimidinergic)
P2RY2 PDF Download   K1722 K1337 X Ca²+(Fluo-4)
P2Y (Purinergic) P2RY4     K1863     Ca²+(Fluo-4)
P2Y (Purinergic) P2RY6 PDF Download   K1717 K1327 X  
P2Y (Purinergic) P2RY11 PDF Download   K1729   X Ca²+(Fluo-4)
P2Y (Purinergic) P2RY14     K1858      
Relaxin RLN3R1   PDF Download K1569   X  
Secretin SCTR PDF Download   K1805   X  
Serotonin HTR1A (5HT1A)   PDF Download K1857   X Phospho-ERK2
Serotonin HTR2B PDF Download   K1847   X  
Serotonin HTR1D   PDF Download K1524      
Serotonin HTR2A   PDF Download K1562 K1613 X  Ca²+(Fluo-4)
Serotonin HTR2C     K1877      Ca²+(Fluo-4)
Serotonin HTR2C            Ca²+(Fluo-4)
Serotonin HTR7 PDF Download   K1704   X  
Somatostatin SSTR1   PDF Download K1570   X  
Somatostatin SSTR2   PDF Download K1582   X  
Somatostatin SSTR5   PDF Download K1575 K1573 X  
Tachykinin TACR1   PDF Download K1801   X  
Tachykinin TACR2 PDF Download   K1844   X Ca²+(Fluo-4), Phospho-ERK2
Tachykinin TACR3   PDF Download K1603   X  
Vasopressin & Oxytocin AVPR1a PDF Download   K1715 K1323 X Ca²+(Fluo-4), Phospho-ERK2
Vasopressin & Oxytocin AVPR2 PDF Download   K1718 K1329 X cAMP
Vasopressin & Oxytocin OXTR PDF Download   K1835   X  
VIP & PACAP VPAC1 PDF Download   K1705   X cAMP
VIP & PACAP VPAC2 PDF Download   K1706   X cAMP
VIP & PACAP ADCYAP1R1 (PAC1) PDF Download   K1525 K1619 X cAMP
Orphan GPR1   PDF Download K1839     cAMP
Orphan GPR21   PDF Download K1840      
Orphan GPR23   PDF Download K1841      
Orphan GPR35     K1872   X  
Orphan GPR39   PDF Download K1842      
Orphan GPR119 PDF Download   K1486   X  
Orphan GPR119   PDF Download K1777 K1770    
Orphan GPR120 (short)   PDF Download K1845      
Orphan GPR132 (G2A) PDF Download   K1749