Life Technologies offers a broad range of cell lines and target assays for functional, ratiometric analysis of GPCRs. GeneBLAzer® and Tango™ parental cell lines enable you to build target assays for any GPCR (Gs, Gq, and Gi/o-coupled), while GeneBLAzer® Validated GPCR Assays provide ready-to-screen capabilities for a wide range of GPCRs.

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Parental Cell Lines for Building your Own GPCR Target Assay

GeneBLAzer® and Tango™ Parental Cell Lines for GPCRs enable you to quickly establish target-specific, ratiometric assays for any GPCR. These parental cell lines are also used to create Invitrogen GeneBLAzer® Validated Functional Assays for GPCRs (see below). GeneBLAzer® and Tango™ parental cell lines:

  • Show the correct EC50 and Z’-Factor = 0.6 for a primary stimulus
  • Are tested and documented for assay performance under variable DMSO concentration, cell number, stimulation time and substrate loading time.
  • Can be engineered with your desired target through our Custom Assay Services program.


Ready-to-screen GeneBLAzer® Validated GPCR Assays

GeneBLAzer® Validated GPCR Assays provide ready-to-screen, ratiometric functional assays for an expanding list of GPCR targets. GeneBLAzer® Validated Assays for GPCRs:

  • Show appropriate EC50 /IC50 and rank order potency to known agonists/antagonists
  • Show a Z’-Factor = 0.6
  • Are tested & documented for assay performance under variable DMSO concentration, cell number, stimulation time, and substrate loading time