LanthaScreen™ fluorescent coregulator peptides for nuclear receptors contain known interaction motifs and are labeled with fluorescein.

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Peptide 100 μl Sequence Description
SRC1-1PV4576KYSQTSHKLV-
QLLTTTAEQQL
Peptide contains the nuclear receptor box1 (LXXLL motif) of SRC-1, member of the p160 coactivator steroid receptor coactivators.1
SRC1-2PV4578LTARHKILHR-
LLQEGSPSD
Peptide contains the nuclear receptor box2 (LXXLL motif) of SRC-1, member of the p160 coactivator steroid receptor coactivators.1
SRC1-3PV4580ESKDHQLLR-
YLLDKDEKDL
Peptide contains the nuclear receptor box3 (LXXLL motif) of SRC-1, member of the p160 coactivator steroid receptor coactivators.1
SRC1-4PV4582GPQTPQAQQ-
KSLLQQLLTE
Peptide contains the nuclear receptor box4 (LXXLL motif) of SRC-1, member of the p160 coactivator steroid receptor coactivators.1
SRC2-1PV4584DSKGQTKLLQ-
LLTTKSDQM
Peptide contains the nuclear receptor box1 (LXXLL motif) of SRC-2, member of the p160 coactivator steroid receptor coactivators.2
SRC2-2PV4586LKEKHKILHRLL-
QDSSSPV
Peptide contains the nuclear receptor box2 (LXXLL motif) of SRC-2, member of the p160 coactivator steroid receptor coactivators.2
SRC2-3PV4588KKKENALLRYLL-
DKDDTKD
Peptide contains the nuclear receptor box3 (LXXLL motif) of SRC-2, member of the p160 coactivator steroid receptor coactivators.2
SRC3-1PV4590ESKGHKKLLQ-
LLTCSSDDR
Peptide contains the nuclear receptor box1 (LXXLL motif) of SRC-3, member of the p160 coactivator steroid receptor coactivators.3
SRC3-2PV4592LQEKHRILHK-
LLQNGNSPA
Peptide contains the nuclear receptor box2 (LXXLL motif) of SRC-3, member of the p160 coactivator steroid receptor coactivators.3
SRC3-3PV4594KKENNALLRY-
LLDRDDPSD
Peptide contains the nuclear receptor box3 (LXXLL motif) of SRC-3, member of the p160 coactivator steroid receptor coactivators.3
CBP-1PV4596AASKHKQLSE-
LLRGGSGSS
This peptide contains the LXXLL motif 1 of CREB binding protein and is involved in ligand-dependent nuclear receptor interactions.4
TRAP220/DRIP-1PV4598KVSQNPILT-
SLLQITGNGG
This peptide is the LXXLL motif 1 of the VDR-interacting proteins which interact in a ligand-dependent manner with nuclear receptors.5
TRAP220/DRIP-2PV4549NTKNHPML-
MNLLKDNPAQD
This peptide is the LXXLL motif 2 of the VDR-interacting proteins which interact in a ligand-dependent manner with nuclear receptors.5
RIP140 L6PV4600SHQKVTLLQ-
LLLGHKNEEN
This peptide is derived from the Nuclear receptor interacting protein 1, LxxLL motif 6, known to interact in a ligand-dependent manner with the activation domains of nuclear receptors.6
RIP140 L8PV4602SFSKNGLLS-
RLLRQNQDSY
This peptide is derived from the Nuclear receptor interacting protein 1, LxxLL motif 8, known to interact in a ligand-dependent manner with the activation domains of nuclear receptors.6
PGC1aPV4421EAEEPSLLK-
KLLLAPANTQ
This peptide is derived from the PPARg coactivator protein 1a and contains an LXXLL motif.7
PRIP/RAP250PV4604VTLTSPLLVNL-
LQSDISAG
This peptide contains the LXXLL-interaction motif of the PPAR interacting protein, PRIP.4
D22PV4386LPYEGSLLLK-
LLRAPVEEV
Peptide was discovered from random phage display and contains sequences that resemble the known coregulatory proteins, RIP140, PCG-1, DAX-1, and SHP.8
C33PV4606HVEMHPLLMG-
LLMESQWGA
Peptide was discovered from random phage display and contains sequences that resemble the known coregulatory proteins, TRAP220 and RIP140.8
EAB1PV4608SSNHQSSR-
LIELLSR
Peptide was discovered from random phage display to find tamoxifen-induced interactions with ER.9
EA2PV4610SSKGVLWRM-
LAEPVSR
Peptide was discovered from random phage display to find tamoxifen-induced interactions with ER.10
TB3PV4614SSVASREW-
WVRELSR
Peptide was discovered by random phage display during tamoxifen-induced interactions with ER.10
AR(16-34)PV4616SKTYRGAFQ-
NLFQSVREVI
This peptide is the N-terminal sequence of AR which mediates a ligand-induced intradomain interaction with the ligand binding domain.11
ARA70PV4618SRETSEKFKL-
LFQSYNVND
This peptide is the FxxLF motif of the AR-specific coactivator, ARA70.11
D11 FxxLFPV4382VESGSSRFM-
QLFMANDLLT
This random phage display peptide had been modified to contain the AR-specific FxxLF interaction motif.11
SMRT ID1PV4620GHQRVVTLA-
QHISEVITQDYTRH
This peptide contains the interaction motif 1 of the corepressor protein, Silencing Mediator for Retinoid and Thyroid-hormone receptors.12
SMRT ID2PV4423HASTNMGLEA-
IIRKALMGKYDQW
This peptide contains the interaction motif 1 of the corepressor protein, Silencing Mediator for Retinoid and Thyroid-hormone receptors.12
NCoR ID1PV4622RTHLITLADH-
ICQIITQDFARN
This peptide contains motif 1 of the Nuclear CoRepressor protein.13
NCoR ID2PV4624DPASNLGLEDII-
RKALMGSFDDK
This peptide contains motif 2 of the Nuclear CoRepressor protein.13

References

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  • Takeshita A, Yen PM, Misiti S, Cardona GR, Liu Y, Chin WW (1996) Endocrinology 137: 3594-3597.
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  • Perissi V, Staszewski LM, McInerney EM, Kurokawa R, Krones A, Rose DW, Lambert MH, Milburn MV, Glass CK, Rosenfeld MG (1999) Genes Dev 13:3198-3208.

For research use only. Not intended for any animal or human therapeutic or diagnostic use.