CellSensor® Cell Lines utilize GeneBLAzer® Technology to provide you with a reliable, rapid, and sensitive method of analyzing the intracellular status of a wide range of disease-relevant signal transduction pathways upon exposure to drug candidates or other stimuli. When the pathway is activated or inhibited, beta-lactamase reporter activity is modulated and can be measured quantitatively and selectively with the GeneBLAzer® Loading Substrates.

Pathway Cell Line SKU Validated Data SelectScreen™ Profiling
Anti-oxidant Response ARE-bla HepG2 K1633 ARE_HepG2_ValPacket_08June2009.pdf available
B cell receptor NFAT-bla RA-1 K1490 NFAT RA-1_Validation Packet_08Sept2008.pdf available
C/EBP C/EBP-bla FreeStyle 293F K1634 CEBP_freestyle_Validation Packet_08Sept2008.pdf  
cAMP/PKA CRE-bla Jurkat K1635 CRE_Jurkat_ValPacket.pdf available
cAMP/PKA CRE-bla FreeStyle 293F K1636 CRE_Freestyle_Validation Packet_08Sept2008.pdf  
cAMP/PKA CRE-bla HEK 293T K1540 CRE_HEK_Validation Packet_08Sept2008.pdf available
cAMP/PKA CRE-bla CHO-K1 K1535    
Cell Cycle pRB-E2F dhfr(E2F)-bla NIH3T3 K1639 dhfr_E2F__NIH3T3_ValPacket_24Oct2008pdf.pdf  
DNA damage/p53 Response p53RE-bla HCT-116 K1640 p53_HCT116_Validation Packet_08Sept2008.pdf available
ER Stress Response ESRE-bla HeLa K1817 ESRE-bla HeLa validation packet 17Dec2008.pdf available
Glucocorticoid Receptor MMTV-bla HeLa K1641 MMTV-bla HeLa Validation Packet 24Oct2008.pdf available
Heat Shock Response HSE-bla HeLa K1813 HSE-bla HeLa_Val Packet_15Sep08.pdf available
Hedgehog Gli-bla 22Rv1 K1838 Gli-bla 22RV1 Validation Packet_24Oct08.pdf  
Hedgehog Gli-bla NIH3T3 K1642 Gli_NIH3T3_ValPacket_24Oct2008.pdf  
Hypoxia HRE-bla HCT116 K1643 HRE_HCT116_Validation Packet_08Sept2008.pdf  
Hypoxia HRE-bla ME-180 K1644 HRE_ME180_Validation Packet_08Sept2008.pdf available
Interleukin 1 IL-1-bla ECV304 K1645 IL-1-bla ECV304_Validation Packet_08Sept2008.pdf  
Interleukin 4/STAT6 STAT6-bla RA1 K1646 STAT6 RA1_V3_Validation Packet_08Sept2008.pdf available
JAK/STAT irf1-bla HEL K1647 irf1_HEL_Validation Packet_08Sept2008.pdf available
JAK/STAT SIE-bla ME-180 K1648 SIE_ME180_Validation Packet_08Sept2008.pdf available
JAK/STAT SIE-bla ME-180 K1648 SIE_ME180_Validation Packet2_08Sept2008.pdf available
JAK/STAT ISRE-bla HEK 293T K1655 ISRE_HEK_Validation Packet_08Sept2008.pdf available
JAK/STAT SIE-bla HEK 293T K1649 SIE_HEK293_Validation Packet_08Sept2008.pdf available
JAK/STAT ISRE-bla Jurkat K1656 ISRE_Jurkat_Validation Packet_08Sept2008.pdf available
JAK/STAT SIE-bla HEK 293T K1649   available
JAK/STAT (IFNg, IL-6/OSM) GAS-bla ME-180 K1651 GAS_ME180_ValPacket_24Oct2008.pdf  
JAK/STAT (IFNg, IL-6/OSM) c-fos-bla ME-180 K1650 cfos_ME180_Validation Packet_08Sept2008.pdf  
JAK/STAT (IFNy, IL-6/OSM) SIE-bla THP-1 K1652 SIE_THP-1_Validation Packet_08Sept2008.pdf  
JAK/STAT (IL-2) irf1-bla CTLL-2 K1653 irf1_CTLL2_Validation Packet_08Sept2008.pdf  
JAK/STAT (IL-3) irf-bla Ba/F3 K1654 irf1_BaF3_Validation Packet_08Sept2008.pdf  
JAK2/STAT5 irf1-bla TF1 K1657 irf1_TF1_Validation Packet_24Octt2008.pdf available
JAK2/STAT5 irf1-bla TF1 K1657 irf1_TF1_Validation Packet2_24Octt2008.pdf available
MAPK c-fos-bla HEK 293T K1659 c-fos-bla HEK293T_Validation Packet_08Sept2008.pdf available
MAPK c-fos-bla ME-180 K1650 cfos_ME180_Validation Packet2_08Sept2008.pdf available
MAPK AP-1-bla HEK 293T K1658 AP1_HEK293T_Validation Packet_08Sept2008.pdf  
MAPK/EGFR/Ras/Raf AP1-bla ME-180 K1661 AP1_ME180_Validation Packet_08Sept2008.pdf available
MAPK/MEK/B-raf AP1-bla A375 K1660 AP1_A375 Validation Packet 24Oct2008.pdf available
Myc Myc-bla HCT-116 K1467 myc-bla HCT116_Validation Packet_08Sept2008.pdf  
NFkB NFkB-bla THP-1 K1662 NFKB_THP-1_Validation Packet_08Sept2008.pdf available
NFkB NFkB-bla ME-180 K1667 NFKB_ME180_Validation Packet_08Sept2008.pdf available
NFkB NFkB-bla Jurkat K1666 NFKB_Jurkat_Validation Packet_08Sept2008.pdf available
NFkB NFkB-bla FreeStyle 293F K1663 NFkB_Freestyle_Validation Packet_08Sept2008.pdf  
NFkB NFkB-bla HEK 293T K1664 NFKB_HEK293T_Validation Packet_08Sept2008.pdf  
NFkB NFkB-bla RA1 K1665 NFkB_RA1_Validation Packet_08Sept2008.pdf  
Notch T-REx NICD-CSL-bla HeLa K1487 TREX-NICD ValPacket_24Oct2008.pdf  
PI3K/AKT/FOXO3 TREx FOXO3-DBE-bla HeLa K1468 T-REx FOXO3 DBE-bla HeLa_Val Packet_08Sept2008.pdf available
PI3K/AKT/mTOR DBE-bla MDA-MB-468 K1814 DBE-bla MDA-MB-468_Val Packet_15Sep08.pdf  
PKC & Ca2+ TrkA-NFAT-bla CHO-K1 K1516 TrkA-NFAT-bla CHO-K1_Val Packet_08Sept2008.pdf available
PKC & Ca2+ TrkB-NFAT-bla CHO-K1 K1491 TrkB NFAT-bla CHO_Validation Packet_08Sept2008.pdf available
PKC & Ca2+ TrkC-NFAT-bla CHO-K1 K1515 TrkC-NFAT-bla CHO-K1_Val Packet_08Sept2008.pdf available
PKC and Ca2+ NFAT-bla HEK293T K1538    
PKC and Ca2+ NFAT-bla CHO-K1 K1534    
PKC/Ca2+ NFAT-bla Jurkat K1671 NFAT-bla_Jurkat_Validation Packet_08Sept2008.pdf available
T Cell Receptor NFAT-bla Jurkat K1671 NFAT-bla_Jurkat_Validation Packet2_08Sept2008.pdf available
TGF beta and BMP SBE-bla A375 K1514 SBE-bla A375 validation packet_20Nov2008.pdf  
TGF-beta SBE-bla HEK 293T K1550 SBE_HEK293T_Validation Packet_08Sept2008.pdf available
TLR3 / TBK1 / IRF3 ISRE-bla RA1 K1674 ISRE RA-1_Validation Packet_08Sept2008.pdf  
TNF alpha TNFa-bla THP-1 K1672    
TNF-alpha/JNK AP1-bla ME-180 K1661 AP1_ME180_Validation Packet2_08Sept2008.pdf available
Toll-Like Receptor NFkB-bla RAW264.7 K1673 NFkB RAW 264.7 Validation Packet 24Oct2008.pdf  
Toll-Like Receptor (TLR4) NFkB-bla THP-1 K1662 NFKB_THP-1_Validation Packet2_08Sept2008.pdf available
Wnt/Beta-Catenin LEF/TCF-bla HCT-116 K1676 LEFTCF_HCT116_Validation Packet_08Sept2008.pdf available
Wnt/Beta-Catenin LEF/TCF-bla FreeStyle 293F K1677 LEFTCF_FS293F_Validation Packet_08Sept2008.pdf  
Wnt/Beta-Catenin (APC-/-) LEF/TCF-bla SW 480 K1675 LEF-TCF-SW480_Validation Packet_08Sept2008.pdf available