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Avoid off target effects with our GPCR toxicity panel

Life Technologies offers a wide panel of well validated cellular assays for screening for selectivity (Table 1) among family members in addition to assays against receptors that currently have marketed drugs directed towards them.  These cellular assays have been built using our powerful GeneBLAzer® beta-lactamase technology, and are available either as dividing cells or in our new Division Arrest (DA) format.

 

Table 1 - GPCR Liability Panel

 

Receptor Dividing Cells Division Arrested Assay Kit
ADORA2AK1245K1345
ADRA2AK1290K1343
AVPR1AK1286K1323
CCKBRK1231K1379
CNR1K1267K1316
CRHR1K1263K1367
D1K1086K1311
EDG3K1234K1319
EDG7K1251K1315
EDNRAK1223K1347
EDNRBK1224K1349
H1K1225K1299
H2K1226K1307
M1K1230K1365