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Let Life Technologies help you evaluate your compound’s transporter interactions.  With a comprehensive offering of transporter-qualified hepatocytes, vesicles, kits and services, we can extend your efforts and accelerate your answers, helping you in the prediction of bioavailability and clearance of your compound, as well as the potential for drug-drug interactions and potential toxicities.

 

GenoMembrane ATP-binding Cassette (ABC) Transporter Vesicles

Pluripotent Stem Cell 

GenoMembrane ATP-binding cassette (ABC) transporter vesicles allow the investigation of possible interactions between specific ABC transporters and your test compounds.

Transporter-Qualified Hepatocytes

 

Primary hepatocytes are effective tools for the in vitro evaluation of metabolism, drug-drug interactions, hepatotoxicity, and transporter assessment.  At Life Technologies, our hepatocyte isolationists are extensively trained in proper techniques to ensure optimal cell health.  As a result, GIBCO® hepatocytes have high viabilities, in vivo-like enzyme expression levels, and if released as plateable cells, excellent confluencies that contribute to polarization and functioning cell-cell contacts.

  • Contain functional membrane receptors and transporters
  • Facilitate effective transporter uptake and basolateral efflux (plated) experiments
  • Have stringent release specs: ≥80% viability and ≥80% confluency (plated cells)