MicroRNAs (miRNAs) are short, highly conserved small noncoding RNA molecules naturally occurring in the genomes of plants and animals. miRNAs are 17–27 nucleotides long and regulate posttranscriptional mRNA expression, typically by binding to the 3’ untranslated region (3’-UTR) of the complementary mRNA sequence, resulting in translational repression and gene silencing. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are “master regulators” of many important biological processes.
Since the discovery of first lin-4 miRNA in C. elegans, miRNAs have been identified in diverse organisms through experimental determination or computational prediction. These are managed through miRBase database which is a public searchable database of all published miRNA sequences and annotation.
Search More Than 2000 Ambion® miRNA Mimics and Inhibitors
Search more than 2000 Ambion® miRNA Mimics and Inhibitors
Search for Pre-Designed miRNA's
Which miRNA Mimic or Inhibitor is right for you?
|Novel design to minimize off-target effects||Next generation chemistries for lowest off-target effects||Chemically modified for good efficacy||Next generation chemistries for highest efficacy|
|Order now||Order now||Order now||Order now|
|Ambion® Pre-miR Precursors||mirVana™ miRNA Mimics||Ambion® Anti-miR Inhibitors||mirVana™ miRNA Inhibitors|
|Function||Mimic endogenous miRNAs||Mimic endogenous miRNAs||Inhibit endogenous miRNAs||Inhibit endogenous miRNAs|
|Content Database||100% Coverage of miRBase v 15*||100% Coverage of miRBase v 19**||100% Coverage of miRBase v 15*||100% Coverage of miRBase v 19**|
|Model System||In Vitro||In Vitro & In Vivo||In Vitro||In Vitro & In Vivo|
|Species Covered||Human||Human, Mouse & Rat (Other species: use custom tool)||Human||Human, Mouse & Rat (Other species: use custom tool)|
|Custom Design Tool||Design your custom miRNAs mimics||Design your custom miRNAs mimics||Design your custom miRNA inhibitors||Design your custom miRNA inhibitors|
|miRNA Libraries||Pre-Designed or Custom Libraries||Designed or Custom Libraries||Designed or Custom Libraries||Designed or Custom Libraries|
|Recommended Catalog #||AM17100: Pre-miR miRNA Precursor 5 nM||4464066: mirVana™ miRNA Mimic 5 nM||AM17000: Anti-miR Inhibitor 5 nM||4464084: mirVana™ miRNA Inhibitor 5 nM|
Additional Products for miRNA Research
miRNAs require special tools for accurate and sensitive analysis. We offer a broad portfolio of products that provides complete solutions for either miRNA expression profiling or a targeted quantitation/target validation.
|miRNA Controls, Customs, & Libraries||miRNA & Small RNA Isolation||Real Time PCR Based miRNA Analysis||miRNA Fluorescent Labeling for Microarrays||miRNA & Non-Coding RNA Microarrays|
Meet the Inventor
miRNA Experimental Planning & Design
New to miRNA Research?
Learn more about miRNAs and their role in current research.
- microRNA overview
- microRNA biogenesis and regulation
- Cellular function and disease
- Target prediction and validation
Need help with your miRNA research? Contact us for a consultation and quote today.
If you have any questions on products or ordering, please contact us at RNAiresearcher@lifetech.com