MicroRNAs (miRNAs) are short, highly conserved small noncoding RNA molecules naturally occurring in the genomes of plants and animals. miRNAs are 17–27 nucleotides long and regulate posttranscriptional mRNA expression, typically by binding to the 3’ untranslated region (3’-UTR) of the complementary mRNA sequence, resulting in translational repression and gene silencing. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are “master regulators” of many important biological processes.

Since the discovery of first lin-4 miRNA in C. elegans, miRNAs have been identified in diverse organisms through experimental determination or computational prediction. These are managed through miRBase database which is a public searchable database of all published miRNA sequences and annotation.

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  Ambion® Pre-miR Precursors mirVana™ miRNA Mimics Ambion® Anti-miR Inhibitors mirVana™ miRNA Inhibitors
Function Mimic endogenous miRNAs Mimic endogenous miRNAs Inhibit endogenous miRNAs Inhibit endogenous miRNAs
Content Database 100% Coverage of miRBase v 15* 100% Coverage of miRBase v 19** 100% Coverage of miRBase v 15* 100% Coverage of miRBase v 19**
Model System In Vitro In Vitro & In Vivo In Vitro In Vitro & In Vivo
Species Covered Human Human, Mouse & Rat (Other species: use custom tool) Human Human, Mouse & Rat (Other species: use custom tool)
Custom Design Tool Design your custom miRNAs mimics Design your custom miRNAs mimics Design your custom miRNA inhibitors Design your custom miRNA inhibitors
miRNA Libraries Pre-Designed or Custom Libraries Designed or Custom Libraries Designed or Custom Libraries Designed or Custom Libraries
Recommended Catalog # AM17100: Pre-miR miRNA Precursor 5 nM 4464066: mirVana™ miRNA Mimic 5 nM AM17000: Anti-miR Inhibitor 5 nM 4464084: mirVana™ miRNA Inhibitor 5 nM

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