Which genome editing technology is right for you?

Transient knockdown of multiple transcripts Transient knockdown with low off-target effects Targeted integration of genetic material into specific integration sites Stable integration of your gene of interest Rapid and efficient editing with multiplexing capabilities Precise and flexible editing; targeting to any gene in any cell
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Ambion® miRNA mimics and inhibitors RNAi Jump-In™ Targeted Integration Kits Flp-In™ System GeneArt® CRISPR Nuclease Vector GeneArt® Precision TALEN™
Modification options Down-regulation (knockdown) Down-regulation (knockdown) Integration (knock-in) Integration (knock-in)
  • Gene deletion (knockout)
  • Down-regulation (knockdown)
  • Integration (knock-in)
  • Gene deletion (knockout)
  • Down-
    regulation (knockdown)
  • Integration (knock-in)
  • Gene activation
Ease of use Pre-designed constructs available for transfection in cell culture Pre-designed constructs available for transfection in cell culture Low effort in vector construction, transfection and clone identification Low effort in vector construction, transfection and clone identification Simple and fast design process Difficult to design (except when using the GeneArt® Precision TALs online design tool)
Type of recognition RNA-RNA RNA-RNA DNA-DNA DNA-DNA RNA-DNA Protein-DNA
Cell type Mammalian Mammalian Mammalian Mammalian Mammalian
  • Mammalian
  • Bacterial
  • Yeast
  • Plants
  • Insect
  • Stem cells
  • Zebrafish
Limitations Only for transient inhibition of translation Only for mRNA cleavage; degradation of mRNA is transient Only for integrations Only for integrations
  • Off-target effects
  • Difficult to design
  • Blocked by CpG methylation
  • Inhibited by chromatin structure
  • Large size for delivery
Off-target effects High Moderate Low Low Moderate Low
Multiplexing capable Capable No No Capable Rarely used